{"id":"W2980213277","doi":"10.1093/annonc/mdz420","title":"Safety, anti-tumour activity, and biomarker results of the HER2-targeted bispecific antibody ZW25 in HER2-expressing solid tumours","year":2019,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Zymeworks (Canada); Jewish General Hospital; Princess Margaret Cancer Centre; University of Ottawa","funders":"","keywords":"Medicine; Response Evaluation Criteria in Solid Tumors; Trastuzumab; Internal medicine; Oncology; Breast cancer; Cancer; Adverse effect; Biomarker; Immunohistochemistry; Adenocarcinoma; Metastatic breast cancer; Gastroenterology; Phases of clinical research; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007911726,0.0002892135,0.0003847277,0.0002756139,0.0001350225,0.0004363986,0.0002552458,0.000299588,0.001058694],"category_scores_gemma":[0.0006512118,0.0001058346,0.0003789625,0.0001834701,0.0002602653,0.0003852683,0.0001123309,0.0006314426,0.0003039258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004293998,"about_ca_system_score_gemma":0.0003327999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007074916,"about_ca_topic_score_gemma":0.0007712381,"domain_scores_codex":[0.9997012,0.00009474289,0.00002402401,0.00004124844,0.00009164293,0.00004709624],"domain_scores_gemma":[0.9997402,0.00005949703,0.0000647364,0.00003191752,0.00005013345,0.00005346978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.0952021,0.007289159,0.02607141,0.0004934472,0.0009689887,0.0007505796,0.0003022689,0.004061346,0.6758974,0.000801502,0.001860156,0.1863016],"study_design_scores_gemma":[0.003788586,0.2521077,0.08400729,0.00005109981,0.00185521,0.00226958,0.0002248009,0.005400815,0.6343182,0.0005441983,0.01537052,0.00006198203],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960725,0.002064346,0.0003905136,0.00006826314,0.00002579138,0.000040859,0.0001644565,0.00002681662,0.001146489],"genre_scores_gemma":[0.9977885,0.000559683,0.0001215398,0.00006704657,0.00001861047,0.0000174248,0.0004160424,0.000007471874,0.00100372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001058694,"threshold_uncertainty_score":0.004184186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07070417056604587,"score_gpt":0.4109842123864601,"score_spread":0.3402800418204142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}