{"id":"W2980223642","doi":"10.1182/blood.v126.23.817.817","title":"Diffuse Large B-Cell Lymphoma Patient-Derived Xenograft Models Capture Molecular and Biologic Heterogeneity and Inform Therapy","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"breakpoint cluster region; Biology; Cancer research; Germinal center; Diffuse large B-cell lymphoma; B-cell receptor; B cell; Lymphoma; Somatic cell; Immunology; Genetics; Gene; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004456778,0.0004773494,0.0003831183,0.000430719,0.000176266,0.0004962918,0.0003502455,0.0004639337,0.002904344],"category_scores_gemma":[0.0001162147,0.0002055805,0.0003358712,0.0002515228,0.000226586,0.0004135802,0.0002170971,0.00135665,0.0007915832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004866393,"about_ca_system_score_gemma":0.0002433695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00105674,"about_ca_topic_score_gemma":0.001541871,"domain_scores_codex":[0.9997641,0.00005424954,0.00002048246,0.00005231007,0.00005994217,0.00004879836],"domain_scores_gemma":[0.9998195,0.00002862864,0.00004184974,0.00004118351,0.00001823228,0.00005066567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006670466,0.001227158,0.001162324,0.00008959788,0.00003377928,0.0001222793,0.0000594017,0.001049082,0.9911532,0.0005560031,0.0004319771,0.003448151],"study_design_scores_gemma":[0.0002778702,0.008782075,0.009252192,0.00002806309,0.0001091722,0.0009365428,0.0001939381,0.01020341,0.9599726,0.000292107,0.009934966,0.00001715534],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860901,0.001550986,0.006981433,0.0001771907,0.00009085715,0.0001783495,0.001979681,0.000203815,0.002747494],"genre_scores_gemma":[0.9908643,0.0007186488,0.003234137,0.00006844469,0.0000115116,0.0001722709,0.001570457,0.00003159736,0.003328733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002904344,"threshold_uncertainty_score":0.009716034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02266553781434518,"score_gpt":0.2379628417692587,"score_spread":0.2152973039549135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}