{"id":"W2980226446","doi":"10.1073/pnas.1907567116","title":"Sublethal antibiotics collapse gut bacterial populations by enhancing aggregation and expulsion","year":2019,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institute for Advanced Research","funders":"National Institute of Child Health and Human Development; National Institute of Allergy and Infectious Diseases; University of Oregon; National Institute of General Medical Sciences; Kavli Foundation; Eunice Kennedy Shriver National Institute of Child Health and Human Development; M.J. Murdock Charitable Trust; National Institutes of Health; National Science Foundation","keywords":"Antibiotics; Ciprofloxacin; Bacteria; Biology; Microbiome; Microbiology; Antimicrobial; Zebrafish; Bioinformatics; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009761399,0.0002192653,0.0002637777,0.0001401233,0.0001246221,0.0002977313,0.0001497464,0.0003261508,0.0004656853],"category_scores_gemma":[0.0001605916,0.0001762988,0.0002096883,0.00007386089,0.0003358531,0.0002555738,0.0003462798,0.0005306043,0.0001692243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003135782,"about_ca_system_score_gemma":0.0001699398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007399815,"about_ca_topic_score_gemma":0.001407741,"domain_scores_codex":[0.9998734,0.00001692637,0.000006995877,0.00002470073,0.00004599234,0.00003188097],"domain_scores_gemma":[0.9998622,0.00002661181,0.00005180986,0.00001559319,0.00001324235,0.00003052037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001116744,0.000003466022,0.0001155003,0.000008542817,0.000001389308,0.00001044457,0.000005998866,0.00003468195,0.9994633,0.00002258219,0.000009595984,0.0003133934],"study_design_scores_gemma":[0.000006119195,0.0001487789,0.01294126,0.000007674079,0.000007727616,0.00009282993,0.0000430739,0.002132505,0.9836724,0.00009216103,0.0008497153,0.000005653812],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942585,0.0005448286,0.004298544,0.0001009641,0.000009858404,0.00001637688,0.0001342733,0.0000674491,0.000569123],"genre_scores_gemma":[0.9965744,0.0003845602,0.002257542,0.00007434571,0.000004408272,0.0000221088,0.00006640388,0.00002039189,0.0005958284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007399815,"threshold_uncertainty_score":0.002275169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02414717453247972,"score_gpt":0.2726690943747588,"score_spread":0.2485219198422791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}