{"id":"W2980256983","doi":"10.1128/aac.01587-19","title":"Metabolomics Study of the Synergistic Killing of Polymyxin B in Combination with Amikacin against Polymyxin-Susceptible and -Resistant Pseudomonas aeruginosa","year":2019,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Amikacin; Polymyxin; Polymyxin B; Pseudomonas aeruginosa; Microbiology; Aminoglycoside; Antibiotics; Chemistry; Biology; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000139481,0.0004031077,0.0004930997,0.0003051225,0.0001768451,0.0002867502,0.0001575363,0.0004139734,0.0007405028],"category_scores_gemma":[0.0001667262,0.0001425259,0.0003635313,0.0003379374,0.0001561283,0.0002783813,0.0002432556,0.0004491649,0.0001656305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002407207,"about_ca_system_score_gemma":0.0002112681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008619307,"about_ca_topic_score_gemma":0.001034019,"domain_scores_codex":[0.9998674,0.00001925702,0.000004806169,0.00003973368,0.00004195753,0.00002686624],"domain_scores_gemma":[0.9999074,0.00001736657,0.00002318841,0.000006684843,0.0000279403,0.00001746203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002530713,0.00002877921,0.0002920715,0.00004150847,0.00001734666,0.00002988831,0.000009277457,0.0001191025,0.9978346,0.00001859494,0.00002292318,0.001332722],"study_design_scores_gemma":[0.00002862728,0.0006481089,0.01508805,0.000008441574,0.00006432852,0.000172963,0.00007639739,0.002890625,0.9795029,0.000100021,0.001397637,0.00002190787],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893517,0.002786929,0.004987948,0.0001669501,0.00005112882,0.0000666714,0.001442793,0.00007313675,0.001072607],"genre_scores_gemma":[0.9888039,0.00146827,0.006355484,0.0002024274,0.00002621444,0.00007309584,0.00111345,0.00002780932,0.001929372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008619307,"threshold_uncertainty_score":0.002477229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005315293602392157,"score_gpt":0.2152835000696416,"score_spread":0.2099682064672495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}