{"id":"W2980337408","doi":"10.1038/s41590-019-0504-0","title":"Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin","year":2019,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; Helse Sør-Øst RHF","keywords":"CD1D; Sphingolipid; Sphingomyelin; Biology; Antigen presentation; Antigen; Ceramide; Cell biology; Lipid signaling; Immunology; Inflammation; T cell; Immune system; Natural killer T cell; Cholesterol; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001067528,0.0001322507,0.0002508642,0.0001626537,0.00006112874,0.000008952527,0.000108513,0.0007102123,0.0008853696],"category_scores_gemma":[0.0001285333,0.0001220496,0.00005014141,0.000127471,0.0001012402,0.0001896506,0.00003277828,0.0006365024,0.0003139902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002495752,"about_ca_system_score_gemma":0.00002414479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001065145,"about_ca_topic_score_gemma":0.00000326025,"domain_scores_codex":[0.9990569,0.0001891701,0.0003237471,0.0002139693,0.00003269318,0.0001835047],"domain_scores_gemma":[0.9992242,0.0001663051,0.0002508611,0.0002027407,0.0001484685,0.000007385059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005317164,0.00003369999,0.0059708,0.00001264312,0.0001950261,2.649169e-7,0.0001159111,0.000003711023,0.9841954,0.00101852,0.00398785,0.003934429],"study_design_scores_gemma":[0.004016233,0.0004123501,0.06643227,0.00002587685,0.00003685253,0.00005160753,0.0002266702,0.00006094387,0.7001743,0.00007687031,0.2283145,0.0001715112],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845435,0.01002403,0.000379492,0.0004772082,0.003115551,0.0003615201,0.000009898663,0.00005633616,0.001032441],"genre_scores_gemma":[0.9957004,0.0003238062,0.00001818047,0.0001281748,0.00002239362,0.000009476069,0.0003453468,0.00001147929,0.003440783],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2840211,"threshold_uncertainty_score":0.9694176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002316321853424607,"score_gpt":0.2126848390546164,"score_spread":0.2103685172011917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}