{"id":"W2980344383","doi":"10.1016/j.stem.2019.09.008","title":"Sphingolipid Modulation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal","year":2019,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"National Cancer Institute; National Human Genome Research Institute; Medical Research Council; Canada Research Chairs; Wellcome Trust; European Hematology Association; Canadian Institutes of Health Research; Terry Fox Foundation","keywords":"Biology; Haematopoiesis; Cell biology; Stem cell; Proteostasis; Progenitor cell; Hematopoietic stem cell; Autophagy; Unfolded protein response; Endoplasmic reticulum; Genetics; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008636103,0.0001554085,0.0001095401,0.0001494873,0.000121147,0.0002671907,0.00006109001,0.00009465613,0.0006850643],"category_scores_gemma":[0.0000889396,0.00006401848,0.00009772612,0.0000905943,0.000136255,0.00012977,0.0001716458,0.0001871887,0.0001689826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002742527,"about_ca_system_score_gemma":0.0002032877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000382009,"about_ca_topic_score_gemma":0.0007781664,"domain_scores_codex":[0.99994,0.00001195315,0.000004658255,0.00001234048,0.00001584336,0.00001512509],"domain_scores_gemma":[0.9999667,0.000004289614,0.00001263518,0.000003987936,0.000004718215,0.000007592468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008909751,0.000006481947,0.0005418035,0.00001304802,0.000002680717,0.00002790342,0.00001137903,0.00006026156,0.9971563,0.0001672266,0.00003040446,0.001893423],"study_design_scores_gemma":[0.000008507063,0.00009491324,0.01028549,0.000004698329,0.00000946516,0.0001553083,0.00003279501,0.000485073,0.9871696,0.0001695211,0.001581823,0.00000287447],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942394,0.001789644,0.002031289,0.0001095921,0.000009829873,0.00002024824,0.00024807,0.00005850859,0.001493408],"genre_scores_gemma":[0.9981767,0.000585643,0.000524453,0.00002646085,0.000003682816,0.000008550196,0.0001405302,0.000004833691,0.0005291564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006850643,"threshold_uncertainty_score":0.002291799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008982461021136345,"score_gpt":0.2145887388273124,"score_spread":0.2056062778061761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}