{"id":"W2980347658","doi":"10.3389/fmicb.2019.02340","title":"Targeted Diphtheria Toxin-Based Therapy: A Review Article","year":2019,"lang":"en","type":"review","venue":"Frontiers in Microbiology","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Immunotoxin; Diphtheria toxin; Targeted therapy; Cancer research; Cancer; Toxin; Antibody; Cancer cell; Medicine; Biology; Immunology; Microbiology; Monoclonal antibody; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000290613,0.0007502893,0.0008171604,0.001618155,0.0002076206,0.0009349167,0.0005216102,0.0008984049,0.005276837],"category_scores_gemma":[0.0002941618,0.0002028904,0.0002820378,0.001780328,0.0002760634,0.001082885,0.0005148913,0.001313132,0.003348693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005268501,"about_ca_system_score_gemma":0.0007592316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005176308,"about_ca_topic_score_gemma":0.0007551275,"domain_scores_codex":[0.9998877,0.00001412524,0.0000133814,0.00002350597,0.00004707773,0.00001426685],"domain_scores_gemma":[0.999874,0.00004907839,0.00001938773,0.000003691091,0.00003456882,0.00001928067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006221186,0.00009830123,0.0001121899,0.01329418,0.00004130133,0.0002305419,0.00005892336,0.0003175267,0.005296472,0.004127411,0.04171235,0.9346485],"study_design_scores_gemma":[0.000006717149,0.00007975833,0.0002746166,0.001452258,0.00003714562,0.0009891764,0.00002674193,0.00005616321,0.0005608356,0.0008226029,0.9956853,0.00000857779],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001824727,0.9967434,0.0002227442,0.0002528454,0.000543842,0.000007286715,0.00002074504,0.00001204992,0.002014788],"genre_scores_gemma":[0.000754225,0.9969468,0.0002451928,0.0002048753,0.0003360032,0.000007749391,0.00004260032,0.000002404556,0.001460258],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005276837,"threshold_uncertainty_score":0.01765275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02387055608603825,"score_gpt":0.2736540286633351,"score_spread":0.2497834725772969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}