{"id":"W2980371692","doi":"10.1182/bloodadvances.2019000350","title":"Targeting chronic lymphocytic leukemia with N-methylated thrombospondin-1–derived peptides overcomes drug resistance","year":2019,"lang":"en","type":"article","venue":"Blood Advances","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Chronic lymphocytic leukemia; Drug; Drug resistance; Thrombospondin 1; Thrombospondin; Leukemia; Cancer research; Chemistry; Medicine; Pharmacology; Immunology; Biology; Biochemistry; Microbiology; Metalloproteinase; Enzyme; Angiogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004261441,0.0005032054,0.0009010096,0.0002223651,0.0002015548,0.00008006688,0.0004103022,0.0001447736,0.0005269331],"category_scores_gemma":[0.0002240508,0.000384023,0.0001566643,0.0008215359,0.0003614116,0.0005969678,0.0001552427,0.000434183,0.0004472923],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.0310703,"about_ca_system_score_gemma":0.02033956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003033004,"about_ca_topic_score_gemma":0.0002089133,"domain_scores_codex":[0.9961586,0.0001119695,0.0005587405,0.0009671866,0.001105104,0.001098418],"domain_scores_gemma":[0.9977443,0.000509961,0.0002689562,0.0009165044,0.0002525417,0.0003077166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008889472,0.0006041756,0.03133288,0.01318026,0.003543006,0.00384125,0.004180085,0.01997597,0.9004499,0.003153863,0.005374973,0.005474144],"study_design_scores_gemma":[0.1844026,0.003064394,0.009120148,0.0083833,0.001579898,0.00132968,0.00308972,0.02785754,0.6315266,0.001246885,0.1247001,0.003699137],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9615225,0.02735947,0.00006198193,0.0001334644,0.0002145653,0.001196981,0.000009230119,0.0003588916,0.009142978],"genre_scores_gemma":[0.9687442,0.002322232,0.005021562,0.0001781149,0.0002837095,0.00007456134,0.00006092289,0.0001224188,0.02319223],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2689233,"threshold_uncertainty_score":0.9998612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005637323439451374,"score_gpt":0.2520790943601666,"score_spread":0.2464417709207152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}