{"id":"W2980396431","doi":"10.1016/j.jalz.2019.06.027","title":"P1‐002: BASE EDITING STRATEGY ALLOWS HIGH FREQUENCY INSERTION OF THE PROTECTIVE A673T MUTATION IN THE APP GENE TO PREVENT THE DEVELOPMENT OF ALZHEIMER'S DISEASE","year":2019,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Biological Research and Disease Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Mutation; Transfection; Exon; Amyloid precursor protein; Gene; Presenilin; Amyloid beta; BACE1-AS; Amyloid (mycology); Alzheimer's disease; Genetics; Medicine; Biology; Molecular biology; Disease; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005002926,0.0001396548,0.0001208665,0.00002546182,0.0001234347,0.00001326723,0.0003440029,0.00005245018,0.00003872194],"category_scores_gemma":[0.0001219534,0.00007088276,0.00008996928,0.000162684,0.00009954342,0.000008142573,0.0002158055,0.00009701352,0.00000852306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004827047,"about_ca_system_score_gemma":0.0001867071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001152512,"about_ca_topic_score_gemma":0.0001671439,"domain_scores_codex":[0.9985674,0.0002824369,0.0003317962,0.0002744205,0.0003042844,0.0002396777],"domain_scores_gemma":[0.9992939,0.00002941442,0.0001473208,0.0003428251,0.0001226005,0.00006393927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005135752,0.0009145326,0.01575311,0.00003912305,0.005353457,0.00000371748,0.001128949,0.0005308857,0.9136316,0.0007094317,0.0005105475,0.06091106],"study_design_scores_gemma":[0.0004379305,0.000317651,0.3811822,0.00003756663,0.0008296067,5.081675e-7,0.0007309061,0.00003635259,0.6152031,0.0007084183,0.0003451738,0.0001705768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818503,0.01562452,0.0001581838,0.0005098595,0.00007239386,0.001592921,0.00003847244,0.000003954366,0.0001494467],"genre_scores_gemma":[0.9988819,0.00003040798,0.0004119927,0.0001943955,0.00006008463,0.0003394571,0.00007138633,0.000008114955,0.000002228098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3654291,"threshold_uncertainty_score":0.2890515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0231585258667727,"score_gpt":0.2768941976774232,"score_spread":0.2537356718106505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}