{"id":"W2980396431","doi":"10.1016/j.jalz.2019.06.027","title":"P1‐002: BASE EDITING STRATEGY ALLOWS HIGH FREQUENCY INSERTION OF THE PROTECTIVE A673T MUTATION IN THE APP GENE TO PREVENT THE DEVELOPMENT OF ALZHEIMER'S DISEASE","year":2019,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Biological Research and Disease Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Mutation; Transfection; Exon; Amyloid precursor protein; Gene; Presenilin; Amyloid beta; BACE1-AS; Amyloid (mycology); Alzheimer's disease; Genetics; Medicine; Biology; Molecular biology; Disease; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002548538,0.0004045652,0.0003697299,0.0002040723,0.0002774616,0.0004328516,0.00047354,0.0006715312,0.003115869],"category_scores_gemma":[0.0002215,0.0001848711,0.0005257499,0.0001949882,0.000248651,0.0001959536,0.0003113618,0.00095485,0.001351028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002073577,"about_ca_system_score_gemma":0.0002464353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008191543,"about_ca_topic_score_gemma":0.000606645,"domain_scores_codex":[0.99977,0.00003195871,0.00002132973,0.00006377471,0.00007202047,0.00004091863],"domain_scores_gemma":[0.9998939,0.00002730782,0.00002829382,0.00001700311,0.00001272367,0.00002076295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000158749,0.0001140313,0.0002118886,0.00006262046,0.00001228947,0.0002789668,0.00003262753,0.0001177578,0.9942695,0.0002413692,0.0003242395,0.004175966],"study_design_scores_gemma":[0.00005027246,0.0007710602,0.002255195,0.00001448452,0.00004582715,0.001272915,0.00003271828,0.001337086,0.9822786,0.00007699087,0.01184801,0.00001695401],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9569863,0.001839019,0.02794818,0.0004573539,0.0004397621,0.0006392267,0.002255236,0.0007623914,0.008672536],"genre_scores_gemma":[0.959425,0.001459794,0.01902292,0.0002885653,0.00006406818,0.0002900093,0.00256798,0.0002331997,0.0166485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003115869,"threshold_uncertainty_score":0.0104236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0231585258667727,"score_gpt":0.2768941976774232,"score_spread":0.2537356718106505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}