{"id":"W2980416038","doi":"10.1089/aid.2017.0205","title":"Absence of HIV-1 Drug Resistance Mutations Supports the Use of Dolutegravir in Uganda","year":2018,"lang":"en","type":"article","venue":"AIDS Research and Human Retroviruses","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of Allergy and Infectious Diseases; Center for AIDS Research, University of Washington; National Institutes of Health; Case Western Reserve University; Government of Canada; Ontario Genomics Institute; Canadian Institutes of Health Research; Johnson Cancer Research Center, Kansas State University; Genome Canada; Ontario Genomics","keywords":"Dolutegravir; Raltegravir; Elvitegravir; Drug resistance; Regimen; Medicine; Virology; Etravirine; Integrase inhibitor; Cart; Resistance mutation; Ritonavir; Reverse-transcriptase inhibitor; Internal medicine; Human immunodeficiency virus (HIV); Viral load; Antiretroviral therapy; Reverse transcriptase; Biology; Genetics; Polymerase chain reaction; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006251907,0.0001006801,0.0002441967,0.0003524747,0.0002031543,0.00002819648,0.0001128193,0.00003804464,0.0001693079],"category_scores_gemma":[0.0002725518,0.00006552708,0.00003926497,0.0004933836,0.0010115,0.0001266597,0.00007291159,0.0001977907,0.00001768837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004987809,"about_ca_system_score_gemma":0.0001949011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003489176,"about_ca_topic_score_gemma":0.002712704,"domain_scores_codex":[0.9984996,0.0001151522,0.0003247086,0.000219416,0.0005267984,0.0003142919],"domain_scores_gemma":[0.9987335,0.0004131365,0.00006980932,0.0003380221,0.0003458,0.00009970575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002881044,0.0002597189,0.968599,0.0001099112,0.00006683758,0.00004747677,0.003735312,1.278111e-7,0.003007658,0.005612761,0.01780995,0.0004631751],"study_design_scores_gemma":[0.001742831,0.000636861,0.9267165,0.0005416408,0.00003268095,0.000007050112,0.001598469,0.00000284052,0.02788809,0.003188754,0.03750256,0.0001416942],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970903,0.0002289023,0.000008015824,0.0007426753,0.00001503091,0.0003509871,0.00002522879,0.000009681715,0.001529124],"genre_scores_gemma":[0.9632325,0.0001343505,0.001100295,0.00002678549,0.0000365896,0.00002391253,0.00002004267,0.00001129779,0.03541424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04188243,"threshold_uncertainty_score":0.3726915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09642557988437224,"score_gpt":0.373704608266775,"score_spread":0.2772790283824028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}