{"id":"W2980416038","doi":"10.1089/aid.2017.0205","title":"Absence of HIV-1 Drug Resistance Mutations Supports the Use of Dolutegravir in Uganda","year":2018,"lang":"en","type":"article","venue":"AIDS Research and Human Retroviruses","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of Allergy and Infectious Diseases; Center for AIDS Research, University of Washington; National Institutes of Health; Case Western Reserve University; Government of Canada; Ontario Genomics Institute; Canadian Institutes of Health Research; Johnson Cancer Research Center, Kansas State University; Genome Canada; Ontario Genomics","keywords":"Dolutegravir; Raltegravir; Elvitegravir; Drug resistance; Regimen; Medicine; Virology; Etravirine; Integrase inhibitor; Cart; Resistance mutation; Ritonavir; Reverse-transcriptase inhibitor; Internal medicine; Human immunodeficiency virus (HIV); Viral load; Antiretroviral therapy; Reverse transcriptase; Biology; Genetics; Polymerase chain reaction; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000967721,0.0002087921,0.0002805497,0.0006274051,0.000642654,0.000788092,0.0003178865,0.0003120548,0.001188174],"category_scores_gemma":[0.004517791,0.0003293316,0.0001579928,0.0003280368,0.0005599452,0.0004229536,0.0007783912,0.0005189951,0.00015197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003665363,"about_ca_system_score_gemma":0.0004997069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003721348,"about_ca_topic_score_gemma":0.006205563,"domain_scores_codex":[0.9994053,0.0002998097,0.0000756954,0.000059664,0.00007019332,0.00008944805],"domain_scores_gemma":[0.9991153,0.0002941111,0.0002857029,0.00006183917,0.0001164155,0.0001266505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004224796,0.00004432328,0.9754951,0.0001098005,0.00002595658,0.00093144,0.0007043862,0.0001505346,0.001553337,0.00008418535,0.0002619018,0.02021657],"study_design_scores_gemma":[0.0001066819,0.0005824429,0.9842421,0.0002796469,0.00007147803,0.006515594,0.002345464,0.001262061,0.001224243,0.0003154841,0.003037381,0.00001735793],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985103,0.0006374246,0.00006649602,0.0001616693,0.000004889393,0.00001066973,0.00006824043,0.000003746529,0.0005365873],"genre_scores_gemma":[0.9994423,0.0002154909,0.0001594149,0.00004716089,0.000003740668,0.000004672158,0.00004433873,0.000001247488,0.000081688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003721348,"threshold_uncertainty_score":0.00739938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09642557988437224,"score_gpt":0.373704608266775,"score_spread":0.2772790283824028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}