{"id":"W2980478025","doi":"10.3390/molecules24203751","title":"Characterization of Redox-Responsive LXR-Activating Nanoparticle Formulations in Primary Mouse Macrophages","year":2019,"lang":"en","type":"article","venue":"Molecules","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; University of Ottawa","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"ABCA1; Liver X receptor; In vivo; Activator (genetics); Chemistry; Transcription factor; Drug delivery; Pharmacology; Cell biology; Biology; Biochemistry; Receptor; Nuclear receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009134152,0.00008307741,0.0002164742,0.0001192078,0.00001823987,0.000008360601,0.00004069028,0.00004522379,0.0000464726],"category_scores_gemma":[0.00006649712,0.00007548572,0.00004139552,0.0001901126,0.00002137317,0.0001224359,0.0000320777,0.00007893541,0.00002119968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002862283,"about_ca_system_score_gemma":0.00004144506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001609657,"about_ca_topic_score_gemma":0.000001979908,"domain_scores_codex":[0.999289,0.00003888825,0.0002460135,0.0001444876,0.0001440465,0.000137596],"domain_scores_gemma":[0.9995743,0.00003273144,0.00009637955,0.0001931854,0.00006269906,0.00004068969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001703014,0.00009967335,0.01939452,0.00007172496,0.000009746054,0.000004153056,0.000598075,0.00002314871,0.9748994,0.0001603407,0.000003154803,0.004565744],"study_design_scores_gemma":[0.000804603,0.00004866582,0.4541303,0.00005626614,0.000007895978,0.000003434547,0.00004115752,0.0002605022,0.5442274,0.00001290259,0.0003616665,0.00004530031],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986043,0.00006215966,0.0001486524,0.0002433311,0.00006416166,0.0003374429,0.00001134955,0.00002467301,0.00050392],"genre_scores_gemma":[0.9978966,0.00001442402,0.000593018,0.0002908397,0.00003654735,0.00001249629,0.00005373191,0.0000167047,0.001085636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4347357,"threshold_uncertainty_score":0.3078218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00816418667365429,"score_gpt":0.2390639784808777,"score_spread":0.2308997918072234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}