{"id":"W2980479341","doi":"","title":"Altered immune phenotypes in subjects with Fabry disease and responses to switching from agalsidase alfa to agalsidase beta.","year":2019,"lang":"en","type":"article","venue":"PubMed","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Globotriaosylceramide; Fabry disease; Enzyme replacement therapy; Immune system; Alpha-galactosidase; T cell; Internal medicine; Medicine; Chemistry; Immunology; Endocrinology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001986229,0.000322132,0.0001785232,0.0006761498,0.000330547,0.0002465366,0.0001321382,0.0004297893,0.002621597],"category_scores_gemma":[0.0006918207,0.0001232302,0.0001450387,0.0003517681,0.0002802965,0.0001886371,0.0001341433,0.0002662341,0.0003135946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001500959,"about_ca_system_score_gemma":0.0001125474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001560771,"about_ca_topic_score_gemma":0.001126236,"domain_scores_codex":[0.9998971,0.00002891382,0.00001161855,0.00002518562,0.00001042119,0.00002681215],"domain_scores_gemma":[0.9997833,0.00005055331,0.00006446952,0.00001651836,0.0000225944,0.00006247337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006588494,0.0004209316,0.8915369,0.0001251803,0.0001238109,0.01294618,0.001182828,0.0001581085,0.0711935,0.0003929168,0.0007842404,0.01454696],"study_design_scores_gemma":[0.00005393089,0.0008835105,0.9866209,0.00001347964,0.00004577714,0.009905228,0.0003714928,0.00009433796,0.001162243,0.0001847906,0.000657585,0.000006571743],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987275,0.0002876265,0.0000504249,0.00004454058,0.000009502292,0.000005630352,0.0001162199,0.000004737597,0.0007537355],"genre_scores_gemma":[0.999049,0.0001052782,0.00006640771,0.00004213594,0.00001314567,0.000005082387,0.0001160399,0.00000178015,0.0006011908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002621597,"threshold_uncertainty_score":0.008770108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01888429766329473,"score_gpt":0.2591698763896867,"score_spread":0.2402855787263919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}