{"id":"W2980479341","doi":"","title":"Altered immune phenotypes in subjects with Fabry disease and responses to switching from agalsidase alfa to agalsidase beta.","year":2019,"lang":"en","type":"article","venue":"PubMed","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Globotriaosylceramide; Fabry disease; Enzyme replacement therapy; Immune system; Alpha-galactosidase; T cell; Internal medicine; Medicine; Chemistry; Immunology; Endocrinology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004733665,0.0002680168,0.0004950305,0.0004386851,0.00006611048,0.00009489911,0.000199396,0.00006888661,0.00009498813],"category_scores_gemma":[0.001030269,0.0002178475,0.00005635432,0.0005695565,0.00003916531,0.0001969365,0.0002287469,0.000287006,0.0001409591],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000167751,"about_ca_system_score_gemma":0.0001414406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001863147,"about_ca_topic_score_gemma":0.0005218271,"domain_scores_codex":[0.9974843,0.0001677324,0.0003132398,0.0006745683,0.0005869192,0.0007732074],"domain_scores_gemma":[0.9978275,0.0003182016,0.00005511855,0.0006374161,0.00009772463,0.001064007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02549014,0.000472052,0.8033217,0.0002456637,0.0001909742,0.0009054709,0.002438513,0.00003071699,0.0171827,0.0000249903,0.0003149098,0.1493822],"study_design_scores_gemma":[0.00334732,0.0001948215,0.991614,0.0001839133,0.00005223565,0.000006861243,0.000311539,0.00003922323,0.003401097,0.00007318266,0.0004875153,0.0002882924],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893892,0.001448014,0.00005597214,0.004926997,0.00008775402,0.003462148,0.00004776331,0.00006552619,0.0005166208],"genre_scores_gemma":[0.9957334,0.00002150382,0.0002578012,0.001248772,0.0001119465,0.001076407,0.000036106,0.00006159505,0.001452466],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1882923,"threshold_uncertainty_score":0.8883563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01888429766329473,"score_gpt":0.2591698763896867,"score_spread":0.2402855787263919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}