{"id":"W2980503825","doi":"10.1016/j.jmb.2019.10.004","title":"The Molecular Basis of MeCP2 Function in the Brain","year":2019,"lang":"en","type":"review","venue":"Journal of Molecular Biology","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":178,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"Wellcome Trust Centre for Mitochondrial Research; Biotechnology and Biological Sciences Research Council; Simons Initiative for the Developing Brain; University of Edinburgh; European Commission; Wellcome Trust","keywords":"Brain function; Computational biology; Basis (linear algebra); Function (biology); Biology; Neuroscience; Evolutionary biology; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002257973,0.0006264308,0.0007916428,0.001288503,0.0002264335,0.0007896594,0.0006983205,0.0008191745,0.002237209],"category_scores_gemma":[0.0002353249,0.0001775348,0.0002359618,0.00109168,0.0004663466,0.0009347221,0.0005538102,0.001182812,0.00183101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006272314,"about_ca_system_score_gemma":0.0008687133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009548969,"about_ca_topic_score_gemma":0.001250108,"domain_scores_codex":[0.999946,0.000007403305,0.000008635124,0.00001234961,0.00001755704,0.000008119068],"domain_scores_gemma":[0.9999393,0.00002250446,0.000008813964,0.000002635217,0.00001696252,0.000009768346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007389131,0.00003760731,0.0002136054,0.01384647,0.00006344427,0.0006014751,0.00007303157,0.0005121305,0.007918394,0.00959938,0.02443335,0.9426272],"study_design_scores_gemma":[0.00001038591,0.00005565302,0.001443021,0.002920984,0.00006925979,0.002721097,0.00007096311,0.0001109247,0.001396019,0.005792551,0.9853899,0.00001932057],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001475797,0.9982796,0.0001182083,0.0002859149,0.0001125383,0.000002203052,0.00001666734,0.000007184047,0.001030053],"genre_scores_gemma":[0.0007924294,0.9983858,0.0001138809,0.00008522364,0.00008726463,0.000003121858,0.00002190804,9.086096e-7,0.0005094844],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002237209,"threshold_uncertainty_score":0.007484198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01850402996633905,"score_gpt":0.3018723368773565,"score_spread":0.2833683069110174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}