{"id":"W2980508816","doi":"10.1002/pmic.201900139","title":"Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2","year":2019,"lang":"en","type":"article","venue":"PROTEOMICS","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Canada Foundation for Innovation","keywords":"Interactome; Intermembrane space; Mitochondrial intermembrane space; Proteases; CLPB; Cell biology; Biology; HEK 293 cells; Biotinylation; Protease; Biochemistry; Enzyme; Mutant; Gene; Bacterial outer membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001059527,0.0002750776,0.000270741,0.0003755184,0.0002190975,0.0004941424,0.0001384845,0.0003129385,0.001190635],"category_scores_gemma":[0.0001879277,0.0001235884,0.0003017103,0.0003061208,0.0001474351,0.0002350784,0.0002619669,0.0003238611,0.0004069587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002416702,"about_ca_system_score_gemma":0.0001258597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000730384,"about_ca_topic_score_gemma":0.001573618,"domain_scores_codex":[0.9998635,0.0000101174,0.000007878819,0.00006032769,0.00003872034,0.00001939429],"domain_scores_gemma":[0.9998977,0.00001837656,0.00003446795,0.00001487989,0.00001273735,0.00002183874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008843846,0.000006199799,0.003228833,0.00002463144,0.00001842075,0.00009145105,0.00001566315,0.00006756742,0.9946508,0.0000668282,0.00006471963,0.00167654],"study_design_scores_gemma":[0.00001354026,0.0001271965,0.1762163,0.000009675902,0.00006834979,0.002610978,0.0000976017,0.006034255,0.8104209,0.0002141368,0.004172908,0.00001421624],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895838,0.001217021,0.007178515,0.0001021396,0.000007156566,0.00001078944,0.00116067,0.00008778846,0.0006521635],"genre_scores_gemma":[0.9895001,0.0004030583,0.006278363,0.0000642659,0.000007062932,0.0000142015,0.002286792,0.00002445645,0.001421609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001190635,"threshold_uncertainty_score":0.00398308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01363019240942182,"score_gpt":0.2520958654374783,"score_spread":0.2384656730280564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}