{"id":"W2980520436","doi":"10.1073/pnas.1820843116","title":"The PedBE clock accurately estimates DNA methylation age in pediatric buccal cells","year":2019,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":291,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Queen's University; Alberta Children's Hospital; BC Children's Hospital; University of Calgary; McGill University; Douglas Mental Health University Institute; Canadian Institute for Advanced Research; St. Joseph’s Healthcare Hamilton; University of British Columbia","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute on Aging; Canadian Institutes of Health Research; Government of Canada; National Institutes of Health; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Institute of Mental Health; Canadian Institute for Advanced Research; University of California Berkeley","keywords":"Epigenetics; Epigenome; DNA methylation; Buccal swab; Biology; Genetics; 5-Hydroxymethylcytosine; Computational biology; Bioinformatics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001244759,0.00007562846,0.00008639261,0.00007026722,0.0001081921,0.00002862509,0.0004737239,0.00009894466,0.000002638423],"category_scores_gemma":[0.0003726515,0.0000460683,0.00005322901,0.000389339,0.0001953158,0.00001984173,0.0001168132,0.00009129564,0.000001871654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001046676,"about_ca_system_score_gemma":0.00003285662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003063591,"about_ca_topic_score_gemma":4.558117e-7,"domain_scores_codex":[0.9989064,0.00000989227,0.0002699991,0.0002004663,0.0004839635,0.0001293003],"domain_scores_gemma":[0.9994259,0.0001015306,0.0002906439,0.00001220209,0.0001510985,0.00001866164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001256852,0.0000154566,0.0316419,0.00002046855,0.000003627842,1.827924e-9,0.00003931784,0.0004907569,0.9642202,0.003170919,0.00007106861,0.0003137111],"study_design_scores_gemma":[0.000120635,0.00005303623,0.1423763,0.000007972572,0.00000550122,3.199732e-7,0.00004498805,0.0005469249,0.842603,0.013739,0.000444561,0.00005775786],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957232,0.0007799493,0.000002527422,0.000500916,0.00003805287,0.000171551,0.000003487493,0.000002195148,0.002778067],"genre_scores_gemma":[0.9986092,0.0004438515,0.0006304168,0.00003722173,0.00008776362,0.000005644354,5.777624e-7,0.000003764776,0.0001815699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1216172,"threshold_uncertainty_score":0.1878611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03533151072754519,"score_gpt":0.3186726480673209,"score_spread":0.2833411373397757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}