{"id":"W2980523680","doi":"10.1161/res.125.suppl_1.485","title":"Abstract 485: STING(ing) the Heart: How DNA Damage and Inflammation Orchestrate Cardiac Remodeling and Heart Failure","year":2019,"lang":"en","type":"article","venue":"Circulation Research","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Heart Institute; Montreal Heart Institute","funders":"","keywords":"Immunostaining; Heart failure; Inflammation; Senescence; DNA damage; Medicine; Downregulation and upregulation; Internal medicine; Pathology; Biology; Cardiology; Immunohistochemistry; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001481496,0.0004590717,0.0002165424,0.0002228122,0.0001437859,0.0002647043,0.0001729716,0.0003952279,0.004962156],"category_scores_gemma":[0.00004899584,0.00009258326,0.0002214111,0.0001542577,0.0002198578,0.000277649,0.0001867037,0.0006470149,0.0006929972],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001839774,"about_ca_system_score_gemma":0.0001279552,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001878585,"about_ca_topic_score_gemma":0.0003451382,"domain_scores_codex":[0.9999397,0.000009593109,0.000006027767,0.00001828954,0.00001358482,0.00001277971],"domain_scores_gemma":[0.9999471,0.000004542929,0.00002202511,0.000004365198,0.000005694877,0.00001628403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002941125,0.00006215768,0.0005223955,0.0002024809,0.00001073742,0.0001134845,0.00001906229,0.00005027848,0.9923728,0.000165655,0.0002903933,0.005896333],"study_design_scores_gemma":[0.00006209354,0.00323522,0.04092886,0.0001310917,0.0001341774,0.002151123,0.0001033651,0.0007586121,0.9362239,0.0003726741,0.01588541,0.00001348044],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9559057,0.02755185,0.007149502,0.001112852,0.0002760831,0.00009716193,0.001597809,0.0002405396,0.006068432],"genre_scores_gemma":[0.9658778,0.01322595,0.003381955,0.0003711599,0.0001885002,0.00006554642,0.00154436,0.00003440627,0.01531038],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004962156,"threshold_uncertainty_score":0.01660001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04505168648779168,"score_gpt":0.3135354269833112,"score_spread":0.2684837404955195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}