{"id":"W2980534320","doi":"10.1200/jco.18.01967","title":"Absolute Improvements in Freedom From Distant Recurrence to Tailor Adjuvant Endocrine Therapies for Premenopausal Women: Results From TEXT and SOFT","year":2019,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":150,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Janssen Pharmaceuticals; National Cancer Institute; Medical Research Council; Takeda Oncology; Canadian Cancer Society Research Institute; National Institutes of Health; Ipsen; Astellas Pharma; National Health and Medical Research Council; Cancer Research UK; National Institute for Health and Care Research; American College of Radiology Imaging Network; NRG Oncology; Bristol-Myers Squibb; National Cancer Research Institute; Cancer Research Institute; NIHR Cambridge Biomedical Research Centre; Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung; Breast Cancer Research Foundation; Sanofi; Oncosuisse; Pfizer","keywords":"Exemestane; Medicine; Tamoxifen; Breast cancer; Internal medicine; Oncology; Gynecology; Estrogen receptor; Population; Adjuvant; Proportional hazards model; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001289788,0.0003308869,0.000662459,0.0002738621,0.00007796205,0.0003554279,0.0001964689,0.0003041998,0.00324862],"category_scores_gemma":[0.002298238,0.0000937551,0.001156466,0.0002659157,0.0001792098,0.0003237657,0.0003142578,0.0004711501,0.000317052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001647317,"about_ca_system_score_gemma":0.0001484136,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002622563,"about_ca_topic_score_gemma":0.0007135937,"domain_scores_codex":[0.9995884,0.0001963309,0.00004479927,0.00005551959,0.00008275805,0.00003207341],"domain_scores_gemma":[0.9988828,0.0004495964,0.0003720953,0.0001151244,0.00005394053,0.000126454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.4928536,0.002632435,0.08719749,0.00212723,0.00617254,0.0001760513,0.0001636253,0.004472179,0.01449382,0.0002762656,0.003893364,0.3855413],"study_design_scores_gemma":[0.07868178,0.179851,0.7071579,0.0004089461,0.01019263,0.0006218251,0.0002236366,0.005111083,0.007934151,0.001495682,0.008233414,0.00008799696],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907347,0.00500433,0.0003838902,0.0003208606,0.00005006296,0.0001012567,0.00135016,0.00003640068,0.002018466],"genre_scores_gemma":[0.9961038,0.000976725,0.0003186358,0.0002972917,0.00008855812,0.00006156934,0.001205814,0.000008623925,0.0009389794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00324862,"threshold_uncertainty_score":0.01086777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0424609352209686,"score_gpt":0.3827609241418298,"score_spread":0.3402999889208612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}