{"id":"W2980549036","doi":"10.1038/s41590-019-0518-7","title":"RBPJ-dependent Notch signaling initiates the T cell program in a subset of thymus-seeding progenitors","year":2019,"lang":"en","type":"article","venue":"Nature Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":93,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Health Science Centre; Sunnybrook Hospital; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; U.S. Department of Health and Human Services; Government of Canada; National Institutes of Health; Canada Research Chairs","keywords":"Notch signaling pathway; Cell biology; Biology; Myeloid; Progenitor cell; T cell; Haematopoiesis; Hes3 signaling axis; HES1; Signal transduction; Immunology; Stem cell; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0006182932,0.0004357701,0.0007595837,0.0003926249,0.0001691046,0.00002297684,0.001063538,0.001950627,0.0007738544],"category_scores_gemma":[0.000111888,0.0003140692,0.0002302148,0.0005519221,0.0005929407,0.0001361553,0.000375444,0.003050988,0.0006816864],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008484753,"about_ca_system_score_gemma":0.0001556055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001783789,"about_ca_topic_score_gemma":0.00006077942,"domain_scores_codex":[0.9969397,0.0005561376,0.0008052887,0.0006369427,0.00009432117,0.0009676259],"domain_scores_gemma":[0.9980398,0.0005973268,0.0004461278,0.0007094569,0.0001893054,0.00001799987],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004664517,0.0006159162,0.01569841,0.00005530615,0.0003056424,0.00001714796,0.0009761438,0.00001218348,0.9771467,0.0008631595,0.0001332966,0.003709587],"study_design_scores_gemma":[0.003138514,0.0009215774,0.003027459,0.00007322796,0.00006568216,0.0001466198,0.00213172,0.000005548728,0.9727545,0.0003631921,0.01699845,0.0003734537],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9583025,0.03474384,0.000003157564,0.0003475826,0.003110688,0.001249343,0.00002982741,0.0001391038,0.002073971],"genre_scores_gemma":[0.9977765,0.0003822289,0.0001008082,0.0001825546,0.00005725933,0.0001430216,0.000158745,0.00004842423,0.001150428],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03947404,"threshold_uncertainty_score":0.9999312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007049457025558611,"score_gpt":0.2353632520080842,"score_spread":0.2283137949825255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}