{"id":"W2980554880","doi":"10.1182/blood-2018-99-112210","title":"Venetoclax in Combination with NAMPT Inhibitors Decreases Mitochondrial Bioenergetics through the Impaired AMPK/SIRT/PGC1α Signaling Pathway in CLL","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Boniface Hospital; University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"","keywords":"AMPK; NAD+ kinase; Cancer research; SIRT3; Biology; Cell biology; Signal transduction; Mitochondrion; Bioenergetics; Venetoclax; PPARGC1A; Sirtuin 1; Chronic lymphocytic leukemia; Coactivator; Protein kinase A; Sirtuin; Biochemistry; Kinase; Downregulation and upregulation; Transcription factor; Leukemia; Immunology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001052866,0.0003234349,0.0004883303,0.0002910017,0.0002213763,0.000239023,0.0002359859,0.0002679745,0.004125471],"category_scores_gemma":[0.0001623842,0.00009775576,0.0003083322,0.0002354508,0.000195075,0.0003098513,0.0001859461,0.001127886,0.0003615401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002737616,"about_ca_system_score_gemma":0.0003881889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001154878,"about_ca_topic_score_gemma":0.003030724,"domain_scores_codex":[0.999936,0.00001442031,0.000005917813,0.00001201218,0.00001213634,0.00001940384],"domain_scores_gemma":[0.9999449,0.000008931409,0.00001440818,0.000004030719,0.000006509319,0.00002116569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0279031,0.003394517,0.001993887,0.002374284,0.0002216594,0.000493214,0.0001796882,0.0006676684,0.8204567,0.0004194778,0.007187718,0.1347081],"study_design_scores_gemma":[0.01209367,0.07328415,0.05350623,0.0006902477,0.001403177,0.003730035,0.0005639389,0.004946064,0.7552912,0.0008983963,0.09347799,0.0001149677],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.94832,0.04330124,0.0008804469,0.0008421916,0.000443021,0.0001508484,0.0008503339,0.0005298947,0.004682073],"genre_scores_gemma":[0.9839655,0.009572087,0.001046735,0.0003989134,0.0001144965,0.0001240472,0.001035363,0.00002671787,0.00371611],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004125471,"threshold_uncertainty_score":0.0138011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009702996695646863,"score_gpt":0.228413405950567,"score_spread":0.2187104092549201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}