{"id":"W2980589859","doi":"10.1016/j.jalz.2019.06.087","title":"P1‐062: A PHASE II STUDY EVALUATING EFFICACY, SAFETY, AND TOLERABILITY OF ORAL BI 425809 IN PATIENTS WITH COGNITIVE IMPAIRMENT DUE TO ALZHEIMER'S DISEASE DEMENTIA","year":2019,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Clinical Dementia Rating; Tolerability; Dementia; Medicine; Placebo; Alzheimer's disease; Population; Clinical endpoint; Internal medicine; Neuropsychology; Disease; Clinical trial; Adverse effect; Psychology; Cognition; Oncology; Psychiatry; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001224671,0.002338757,0.002286743,0.0004527604,0.0004401231,0.001109475,0.00107388,0.001467085,0.00618554],"category_scores_gemma":[0.0007056843,0.0007933662,0.00115262,0.0003843918,0.0008583096,0.001059693,0.0003797598,0.003400529,0.001979898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004538502,"about_ca_system_score_gemma":0.001551859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009746124,"about_ca_topic_score_gemma":0.001962265,"domain_scores_codex":[0.9997248,0.0001047218,0.00001371764,0.00005659093,0.00003203116,0.00006809875],"domain_scores_gemma":[0.9996064,0.00005261309,0.00005546054,0.00003376209,0.00004033585,0.0002114847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7644558,0.1077794,0.001859269,0.001326138,0.001332261,0.0002855575,0.0002402595,0.0009799647,0.05182053,0.0003160729,0.005275488,0.06432932],"study_design_scores_gemma":[0.6153551,0.3750852,0.004461451,0.0000310938,0.0003622664,0.000161318,0.00005423589,0.0006220554,0.001928817,0.000171364,0.00173217,0.00003496043],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854659,0.002225229,0.0009486576,0.0005061124,0.0001992044,0.005200791,0.001930501,0.0002793427,0.003244197],"genre_scores_gemma":[0.9687498,0.004172682,0.003149531,0.001952772,0.0003125671,0.00818687,0.004517965,0.00008499165,0.008872866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00618554,"threshold_uncertainty_score":0.02069265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0280931434652845,"score_gpt":0.3511163589046463,"score_spread":0.3230232154393617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}