{"id":"W2980591680","doi":"10.1101/792184","title":"Cathepsin g degrades synovial fluid lubricin: relevance for osteoarthritis pathogenesis","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Bone and Joint Health Institute; University of Calgary","funders":"Vetenskapsrådet; Göteborgs Universitet; AFA Försäkring","keywords":"Osteoarthritis; Synovial fluid; Cathepsin G; Cathepsin D; Proteases; Mucin; Chemistry; Aggrecanase; Cathepsin L; Western blot; Cathepsin; Protease; Biochemistry; Molecular biology; Medicine; Enzyme; Pathology; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002401352,0.0003953488,0.0002707968,0.0003413933,0.0001384485,0.0003454409,0.0001296181,0.0004210705,0.0008819292],"category_scores_gemma":[0.000258575,0.00009284638,0.0002862809,0.0002033913,0.0003658065,0.0001694406,0.0001853344,0.0002548652,0.0002959684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002744989,"about_ca_system_score_gemma":0.0001805933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004228774,"about_ca_topic_score_gemma":0.0001697123,"domain_scores_codex":[0.999916,0.00001992453,0.000008963062,0.00001522254,0.00001376864,0.00002612312],"domain_scores_gemma":[0.9999157,0.00001173253,0.00003178584,0.000008205631,0.00001044892,0.00002203161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001687726,0.00006793517,0.01895094,0.0002387647,0.00005849173,0.001972145,0.0001239489,0.0001199371,0.9669867,0.0004162463,0.0003360829,0.009041087],"study_design_scores_gemma":[0.0002723468,0.00127006,0.2873307,0.00008293935,0.0002220866,0.01613629,0.0004287421,0.002988056,0.6812342,0.00161656,0.008390967,0.00002701402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855574,0.0120575,0.001246847,0.0003368729,0.00003219319,0.0000166574,0.0001217253,0.00003397676,0.0005968236],"genre_scores_gemma":[0.9974324,0.001438219,0.0004800558,0.00004381352,0.00002190758,0.00000585902,0.0001090574,0.000003299866,0.0004653713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008819292,"threshold_uncertainty_score":0.00295037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01614192888207134,"score_gpt":0.2303230017987847,"score_spread":0.2141810729167134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}