{"id":"W2980607677","doi":"10.1007/s10534-019-00222-3","title":"DIBI, a novel 3-hydroxypyridin-4-one chelator iron-binding polymer, inhibits breast cancer cell growth and functions as a chemosensitizer by promoting S-phase DNA damage","year":2019,"lang":"en","type":"article","venue":"BioMetals","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Mitacs","keywords":"Chemosensitizer; Cancer cell; Breast cancer; DNA damage; Cell cycle; Cisplatin; Transferrin receptor; Chemistry; Apoptosis; Doxorubicin; Growth inhibition; Cancer research; Pharmacology; Ferritin; Ferroportin; Reactive oxygen species; Cancer; Cell growth; Transferrin; Biology; Chemotherapy; Biochemistry; Internal medicine; Cytotoxicity; Medicine; In vitro; DNA; Metabolism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002881751,0.0003624739,0.0005692877,0.0002301858,0.0001892076,0.00006609707,0.00007802359,0.0003140292,0.000720383],"category_scores_gemma":[0.00005352267,0.0003119076,0.0001533412,0.0007412311,0.0001406454,0.0002486741,0.0001161074,0.0003112423,0.0001953322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001063744,"about_ca_system_score_gemma":0.0001398066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005944517,"about_ca_topic_score_gemma":0.000004698961,"domain_scores_codex":[0.997958,0.00003761171,0.000451128,0.0006331332,0.0003347227,0.0005853905],"domain_scores_gemma":[0.9988937,0.00005961668,0.0002089079,0.0003165261,0.00008437251,0.0004368569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001243635,0.0009081684,0.00159951,0.0003946922,0.0001760652,0.00001380232,0.0004279822,1.668818e-7,0.9936975,0.00002508344,0.0006375637,0.001995129],"study_design_scores_gemma":[0.01313799,0.0005363592,0.0008924557,0.0006272677,0.0006484778,0.0004237766,0.001355486,0.0008451411,0.9793168,0.00000560354,0.001510627,0.0007000683],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881368,0.003543494,0.00002033419,0.002157236,0.0002869889,0.0006881263,0.0004271902,0.0001314982,0.004608312],"genre_scores_gemma":[0.9902114,0.0003869295,0.00006949259,0.0005319299,0.0001284361,0.00003207619,0.0001574609,0.00008244992,0.008399833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01438073,"threshold_uncertainty_score":0.9999333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007584241556498852,"score_gpt":0.242277748411576,"score_spread":0.2346935068550772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}