{"id":"W2980610466","doi":"10.1172/jci.insight.127889","title":"Rb1/Rbl1/Vhl loss induces mouse subretinal angiomatous proliferation and hemangioblastoma","year":2019,"lang":"en","type":"article","venue":"JCI Insight","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute","funders":"Foundation Fighting Blindness; Ohio State University; Canadian Cancer Society Research Institute; National Institutes of Health; Sichuan University; Krembil Foundation; National Cancer Institute; West China Hospital, Sichuan University; National Natural Science Foundation of China; University of Ottawa; Canadian Institutes of Health Research; Imperial College London","keywords":"Retina; Retinal; Retinoblastoma; Angiogenesis; Biology; Cell biology; Cyclin D1; Cancer research; Gene; Cell cycle; Genetics; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001586719,0.0004126311,0.0002295671,0.0005926074,0.000168744,0.0002807549,0.0002346747,0.0003483131,0.00154579],"category_scores_gemma":[0.00009238791,0.0002988635,0.0002627639,0.0002004109,0.0003553854,0.000188885,0.0001779103,0.0007071684,0.0005797466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005357928,"about_ca_system_score_gemma":0.0001985928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001046698,"about_ca_topic_score_gemma":0.001345093,"domain_scores_codex":[0.9997495,0.00003539148,0.00002274401,0.00005395146,0.00007779094,0.00006054182],"domain_scores_gemma":[0.9997709,0.00003039617,0.00009724178,0.00002943857,0.00001055086,0.00006132424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000637638,0.00002726118,0.00009432121,0.00001267371,0.000003678231,0.00005132016,0.00001252986,0.00006901215,0.9990194,0.0001405474,0.00002715609,0.0004784589],"study_design_scores_gemma":[0.00001823917,0.0001539134,0.001682196,0.000003835632,0.00001054729,0.0001888205,0.00001272786,0.0009378745,0.9956757,0.00005431851,0.001259262,0.000002470912],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914855,0.001088549,0.004042902,0.0001233474,0.0000224882,0.00003792155,0.0006773353,0.000373786,0.002148217],"genre_scores_gemma":[0.9912503,0.000511492,0.0023622,0.00004253372,0.000009604186,0.00003693357,0.0005763479,0.00009604466,0.005114635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00154579,"threshold_uncertainty_score":0.00517118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00607316741393953,"score_gpt":0.218767657925426,"score_spread":0.2126944905114865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}