{"id":"W2980610466","doi":"10.1172/jci.insight.127889","title":"Rb1/Rbl1/Vhl loss induces mouse subretinal angiomatous proliferation and hemangioblastoma","year":2019,"lang":"en","type":"article","venue":"JCI Insight","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute","funders":"Foundation Fighting Blindness; Ohio State University; Canadian Cancer Society Research Institute; National Institutes of Health; Sichuan University; Krembil Foundation; National Cancer Institute; West China Hospital, Sichuan University; National Natural Science Foundation of China; University of Ottawa; Canadian Institutes of Health Research; Imperial College London","keywords":"Retina; Retinal; Retinoblastoma; Angiogenesis; Biology; Cell biology; Cyclin D1; Cancer research; Gene; Cell cycle; Genetics; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008093569,0.000168202,0.0001781309,0.00007516801,0.00007877334,0.0000873632,0.0001078305,0.0001760353,0.00003600662],"category_scores_gemma":[0.00002061208,0.0001589325,0.00007404062,0.00008654807,0.0000678614,0.0000126462,0.00008754455,0.00007842023,0.00005167498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001192863,"about_ca_system_score_gemma":0.00007831125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000410462,"about_ca_topic_score_gemma":0.0001185665,"domain_scores_codex":[0.999051,0.00003800745,0.0001746717,0.0003624816,0.0001411711,0.0002326412],"domain_scores_gemma":[0.9994509,0.000006368552,0.00007641722,0.0002973992,0.00007378027,0.00009511751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001349841,0.00007606208,0.004159241,0.00004325122,0.00004826678,0.000003692213,0.0002069898,0.000006178224,0.9884997,0.0002818506,0.004217956,0.002321841],"study_design_scores_gemma":[0.0008676787,0.00025951,0.00572077,0.00001325962,0.00002356829,0.00009418916,0.00004339068,0.00003302508,0.520075,0.00003511392,0.4725631,0.0002714184],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932119,0.003911471,0.00004757498,0.0001293907,0.0005733342,0.0002774721,0.00001585916,0.00002617301,0.00180684],"genre_scores_gemma":[0.9947831,0.000526022,0.0001632096,0.0003358528,0.001160448,0.00002851399,0.00007695518,0.00002885474,0.002897023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4684247,"threshold_uncertainty_score":0.648108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00607316741393953,"score_gpt":0.218767657925426,"score_spread":0.2126944905114865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}