{"id":"W2980612146","doi":"10.1182/blood.v118.21.903.903","title":"Ferritin-H and a Phytotherapeutic, Alone or Combined, Reprogram RBC Precursor Cells From SCD Patients to Produce Levels of Fetal Hemoglobin That Constitute a Phenotypic Cure for Sickle Cell As Well As Providing Resistance to Malaria and a Probable Treatment for Beta-Thalassemia","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Cure Foundation","funders":"","keywords":"Biology; Fetal hemoglobin; Globin; Phenotype; Transgene; Fetus; Hemoglobinopathy; Ferritin; Immunology; In vivo; Gene; Molecular biology; Hemolytic anemia; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000099572,0.0001710599,0.0001936769,0.0002011079,0.00009532642,0.0001460942,0.000109192,0.000226726,0.002294774],"category_scores_gemma":[0.00005503561,0.00006223343,0.0001803663,0.00009943925,0.0001463203,0.00007310683,0.00009900713,0.0004001992,0.0004183444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000103653,"about_ca_system_score_gemma":0.000156768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002953449,"about_ca_topic_score_gemma":0.0005629323,"domain_scores_codex":[0.9999561,0.000007173919,0.000004162805,0.000009654308,0.0000116879,0.00001113435],"domain_scores_gemma":[0.9999605,0.00001069542,0.000005724472,0.000005360153,0.000004640985,0.00001302446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004448077,0.0001925201,0.0002133867,0.00003292111,0.000006047936,0.00005438603,0.00001708651,0.00005021249,0.9947149,0.00008521994,0.0001346535,0.004053893],"study_design_scores_gemma":[0.0001540276,0.003049487,0.003532158,0.000007744689,0.00003888383,0.0003549684,0.00002203903,0.0005777736,0.9895512,0.00005522692,0.002652516,0.000003846578],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939844,0.0006552718,0.002561851,0.00009700784,0.00004690067,0.00007336893,0.0003079004,0.000118002,0.002155274],"genre_scores_gemma":[0.991847,0.0005197421,0.003148479,0.00007415311,0.00001853529,0.00004719054,0.0005754738,0.00001952053,0.003749801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002294774,"threshold_uncertainty_score":0.00767678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0308212087226852,"score_gpt":0.2571386212543619,"score_spread":0.2263174125316767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}