{"id":"W2980619499","doi":"10.1073/pnas.1820838116","title":"Biological embedding of experience: A primer on epigenetics","year":2019,"lang":"en","type":"review","venue":"Proceedings of the National Academy of Sciences","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":265,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute; University of British Columbia; Hospital for Sick Children; SickKids Foundation; BC Children's Hospital; University of Toronto; Vector Institute; Canadian Institute for Advanced Research","funders":"","keywords":"Epigenome; Epigenetics; DNA methylation; Biology; Computational biology; Biological data; Epigenesis; Genetics; Evolutionary biology; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001798884,0.001506905,0.001948294,0.004440103,0.0007518023,0.002850574,0.002006971,0.00384489,0.003196335],"category_scores_gemma":[0.001721733,0.0004604036,0.0006548411,0.003137838,0.005371656,0.006809334,0.002307761,0.007140638,0.002346415],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002044562,"about_ca_system_score_gemma":0.001627699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001687352,"about_ca_topic_score_gemma":0.00196358,"domain_scores_codex":[0.9995337,0.0001786874,0.00005307814,0.00007550712,0.0001250041,0.00003414168],"domain_scores_gemma":[0.9987375,0.0009406553,0.00005901768,0.00005031665,0.00013154,0.00008094472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009463704,0.00007875642,0.0002902208,0.01103637,0.0000844354,0.0006317999,0.001265446,0.0006040536,0.002279726,0.1615513,0.1251465,0.6969367],"study_design_scores_gemma":[0.00000352573,0.0000264398,0.0002532905,0.002341202,0.00001081086,0.0006109749,0.0001722681,0.00005128956,0.0001563798,0.01819554,0.9781625,0.00001586411],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004839692,0.9932394,0.0006046192,0.002586866,0.001658311,0.000004488758,0.0000109117,0.000008263257,0.001838715],"genre_scores_gemma":[0.0009782817,0.9913809,0.0007165727,0.002405832,0.002523998,0.00002101269,0.00002072319,0.000007540742,0.001945062],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004440103,"threshold_uncertainty_score":0.0148344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1472050724086145,"score_gpt":0.4201761856096547,"score_spread":0.2729711132010402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}