{"id":"W2980660791","doi":"10.1101/805457","title":"Persistent DNA Hyper-methylation Dampens Host Anti-Mycobacterial Immunity","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Global Health Research","funders":"National Institutes of Health","keywords":"DNA methylation; Immunity; Biology; Immune system; Immunology; Innate immune system; Methylation; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001889141,0.000210153,0.0002605243,0.000246582,0.0001382082,0.0003915999,0.0001201569,0.0003108724,0.003821259],"category_scores_gemma":[0.0001576119,0.000174643,0.0001641804,0.000130243,0.0002080586,0.0001765775,0.0002001877,0.0005276891,0.0005293942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001712417,"about_ca_system_score_gemma":0.0001193179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004877297,"about_ca_topic_score_gemma":0.0007156398,"domain_scores_codex":[0.9998515,0.0000250339,0.00001008727,0.00004747456,0.00003801741,0.00002780716],"domain_scores_gemma":[0.9999053,0.00001684202,0.0000308999,0.00001111959,0.00001586011,0.00001998925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001320636,0.00001590856,0.002359822,0.00008098489,0.000016091,0.00002117934,0.00002259196,0.00007114881,0.9944257,0.0000399754,0.0001516614,0.002662801],"study_design_scores_gemma":[0.00003356508,0.0005638039,0.09276574,0.00005427427,0.00006221585,0.0005564429,0.0001583339,0.001933746,0.8951765,0.0003538807,0.008327912,0.00001350292],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9809733,0.00861839,0.004966593,0.000397182,0.00009718346,0.00003215706,0.001984318,0.0003538588,0.002577029],"genre_scores_gemma":[0.9937064,0.001155134,0.001518119,0.0001710244,0.00002347907,0.00003402139,0.0007556205,0.00002180303,0.002614489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003821259,"threshold_uncertainty_score":0.01278335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02902723470772287,"score_gpt":0.2737257357930296,"score_spread":0.2446985010853067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}