{"id":"W2980665363","doi":"10.1182/blood-2018-99-116796","title":"Mechanical Loading Shows Anti-Myeloma Effects While Rescuing Bone Loss with Net Bone Formation in a Myeloma Bone Disease Murine Model","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Children's Hospital","funders":"","keywords":"Bone resorption; Medicine; Bone remodeling; Bone marrow; Multiple myeloma; Osteolysis; Bone disease; Resorption; In vivo; Pathology; Bone healing; Internal medicine; Osteoporosis; Anatomy; Surgery; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002091751,0.0007120967,0.0005140937,0.0006894526,0.0002681109,0.0002796318,0.0003945218,0.000780982,0.001703534],"category_scores_gemma":[0.00007223195,0.0002321831,0.0005506484,0.0003737821,0.0004468675,0.0002373531,0.0001898263,0.00156542,0.0004653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003308655,"about_ca_system_score_gemma":0.0002809689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001448715,"about_ca_topic_score_gemma":0.002182066,"domain_scores_codex":[0.9996122,0.00003886411,0.00003415023,0.00008508576,0.0001304001,0.00009938089],"domain_scores_gemma":[0.9997831,0.0000178373,0.00006995623,0.00002667958,0.00002016727,0.00008227952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000222034,0.0002361348,0.0001294371,0.00003557338,0.000004724787,0.00002754597,0.00001225201,0.00008819639,0.9983979,0.00004823651,0.00005876485,0.000739172],"study_design_scores_gemma":[0.00004276471,0.002348653,0.003053962,0.000007520547,0.00002033179,0.0001246854,0.00002817343,0.0008440979,0.9922132,0.0000417278,0.00126782,0.000007030112],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990789,0.001434872,0.004159725,0.0002400687,0.00009815345,0.00009437067,0.001363472,0.0002720314,0.001548336],"genre_scores_gemma":[0.9876413,0.001010563,0.004393633,0.0001500193,0.00003300248,0.0001730467,0.001161862,0.00005012889,0.005386578],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001703534,"threshold_uncertainty_score":0.00569886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01951311393566581,"score_gpt":0.2719212554287835,"score_spread":0.2524081414931177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}