{"id":"W2980682431","doi":"10.1152/ajpcell.00339.2019","title":"The load dependence and the force-velocity relation in intact myosin filaments from skeletal and smooth muscles","year":2019,"lang":"en","type":"article","venue":"American Journal of Physiology-Cell Physiology","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Research Council Canada; Government of Canada","keywords":"Myosin; Actin; Biophysics; Myosin head; Protein filament; Skeletal muscle; Sarcomere; Stiffness; Chemistry; Muscle contraction; Microfilament; Myofilament; Meromyosin; Mechanics; Anatomy; Materials science; Cytoskeleton; Physics; Myosin light-chain kinase; Biology; Myocyte; Biochemistry; Cell biology; Composite material","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003851826,0.000288585,0.0002885344,0.0004840873,0.0002454694,0.0002720527,0.0004168421,0.0005533635,0.001359502],"category_scores_gemma":[0.0008580466,0.000256808,0.0002007883,0.0002071202,0.0003252355,0.0006390891,0.0002599994,0.0005763744,0.000278302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002447942,"about_ca_system_score_gemma":0.0001368229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006642269,"about_ca_topic_score_gemma":0.001009961,"domain_scores_codex":[0.9996524,0.00004362865,0.00002461176,0.00006243041,0.000155074,0.00006188836],"domain_scores_gemma":[0.9991968,0.0003714357,0.0001526848,0.00006855462,0.0001212638,0.00008927593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003648721,0.00001358007,0.0002678675,0.00002138839,0.000003430372,0.00003457391,0.00003140656,0.00005529708,0.9986584,0.00004108417,0.000005627675,0.0008308913],"study_design_scores_gemma":[0.0000201043,0.0006363395,0.04893181,0.00001277078,0.00002738678,0.0003435807,0.00007659059,0.004923393,0.9435173,0.000221133,0.001268221,0.00002136239],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880974,0.002965237,0.007584115,0.00007567252,0.00003180047,0.00003906321,0.0001010178,0.00004723738,0.001058442],"genre_scores_gemma":[0.9901153,0.001060602,0.006830925,0.00005702511,0.00003049954,0.00005043363,0.0003025435,0.00003254508,0.001520182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001359502,"threshold_uncertainty_score":0.004547954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005084573738927513,"score_gpt":0.2290662231687335,"score_spread":0.223981649429806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}