{"id":"W2980752817","doi":"10.1101/806851","title":"Exosomes transmit retroelement RNAs to drive inflammation and immunosuppression in Ewing Sarcoma","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Princess Margaret Cancer Centre; University Health Network; University of British Columbia; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research; Conquer Cancer Foundation; National Institutes of Health; Government of Ontario; Bundesministerium für Bildung und Forschung; Kræftens Bekæmpelse","keywords":"Proinflammatory cytokine; Microvesicles; Immune system; Biology; Immunosuppression; Inflammation; Cancer research; Immunology; Extracellular vesicles; Malignancy; Phenotype; CD8; microRNA; Gene; Genetics; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001974038,0.0001397701,0.0001209957,0.0001865796,0.0001134943,0.0002660504,0.00005488058,0.0001762784,0.0008010128],"category_scores_gemma":[0.0001424662,0.0000692853,0.0001451431,0.0001006311,0.0001677952,0.0001633276,0.00027258,0.0002856909,0.0002648535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00017888,"about_ca_system_score_gemma":0.0001068844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001194241,"about_ca_topic_score_gemma":0.0001239272,"domain_scores_codex":[0.9999377,0.00001383372,0.000005543462,0.0000134561,0.00001795609,0.00001143213],"domain_scores_gemma":[0.9999537,0.00001115587,0.00001167487,0.000008176679,0.000004820635,0.00001041523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000166517,0.00002147218,0.003682832,0.00004021441,0.00001136815,0.0003219932,0.00005452692,0.0001954793,0.9908132,0.0008512774,0.0001795919,0.003661575],"study_design_scores_gemma":[0.00004293807,0.0002738554,0.02599982,0.00001710084,0.00003401492,0.00218109,0.0001168517,0.002175088,0.9602246,0.00131899,0.007608252,0.000007514842],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956294,0.001206117,0.001884752,0.0001132743,0.00002988383,0.00001295724,0.0002133221,0.0000368945,0.0008734523],"genre_scores_gemma":[0.9971088,0.0004918511,0.0008695326,0.00003632253,0.00001505377,0.000009896703,0.0001920647,0.00001144043,0.001265024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008010128,"threshold_uncertainty_score":0.002679706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007069102410718767,"score_gpt":0.2189348231385462,"score_spread":0.2118657207278275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}