{"id":"W2980762329","doi":"10.1182/blood-2018-99-116577","title":"Practical Utilisation of Octapharma FVIII Concentrates in Previously Untreated and Minimally Treated Haemophilia a Patients Entering Routine Clinical Treatment with Nuwiq®, Octanate® or Wilate® — the Protect-NOW Study","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Immunogenicity; Haemophilia A; Haemophilia; Cumulative incidence; Titer; Interim analysis; Clinical trial; Von Willebrand factor; Internal medicine; Immunology; Surgery; Cohort; Antibody","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002358522,0.0003825889,0.000728387,0.000284677,0.0002859615,0.0007906537,0.0004170191,0.0007155021,0.002369654],"category_scores_gemma":[0.002850464,0.0002071066,0.0008642256,0.000303237,0.000453206,0.0006401928,0.0005169656,0.001059543,0.000335738],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000740855,"about_ca_system_score_gemma":0.0007839855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006551504,"about_ca_topic_score_gemma":0.0005704065,"domain_scores_codex":[0.998231,0.0010422,0.0001229285,0.0002855557,0.0001975511,0.0001207824],"domain_scores_gemma":[0.9981384,0.0004838823,0.0005773314,0.0001293432,0.0001201702,0.0005508714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5149959,0.04539934,0.2338263,0.0008444992,0.001187495,0.0005825444,0.001302377,0.001149665,0.009656398,0.0005759256,0.001217995,0.1892615],"study_design_scores_gemma":[0.03137137,0.7385839,0.2212553,0.0001085555,0.0007860253,0.0005921274,0.0005469391,0.0009011403,0.002626461,0.000176994,0.002998663,0.00005265207],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982941,0.0008237519,0.0001184152,0.00006407544,0.00001545622,0.0001764354,0.0001035783,0.000003641369,0.0004005475],"genre_scores_gemma":[0.9987477,0.0003614968,0.000248631,0.00008390957,0.00004622565,0.0001826939,0.0001703515,0.000001653932,0.0001574193],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002369654,"threshold_uncertainty_score":0.01247323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07312230138839558,"score_gpt":0.3859557139712627,"score_spread":0.3128334125828671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}