{"id":"W2980770585","doi":"10.1128/msystems.00416-19","title":"Genomewide Analysis of Mode of Action of the <i>S</i> -Adenosylmethionine Analogue Sinefungin in Leishmania infantum","year":2019,"lang":"en","type":"article","venue":"mSystems","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; Government of Canada; National Institutes of Health; National Institute of General Medical Sciences; Canada Research Chairs","keywords":"Leishmania infantum; Biology; Leishmania; Nucleoside; Mode of action; Function (biology); Parasite hosting; Computational biology; Biochemistry; Genetics; Leishmaniasis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001168498,0.0001171506,0.0001983776,0.0003150321,0.00008390526,0.000181785,0.0001086127,0.0002412976,0.001123476],"category_scores_gemma":[0.0001543725,0.00008611858,0.0002404142,0.0002867004,0.00009508457,0.00005080807,0.0001153217,0.000223931,0.0001483371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000847483,"about_ca_system_score_gemma":0.00007325547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008931869,"about_ca_topic_score_gemma":0.001398552,"domain_scores_codex":[0.9999226,0.00001242575,0.000003626841,0.00003509111,0.00001236845,0.00001383936],"domain_scores_gemma":[0.9998993,0.0000308001,0.00003823751,0.000008305165,0.000008118674,0.00001521742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004356912,0.00002675642,0.02171525,0.00005745607,0.0000933703,0.0001262934,0.00004486027,0.0001503668,0.9724796,0.00007443022,0.00008776927,0.004708199],"study_design_scores_gemma":[0.00002116912,0.0005118006,0.9195046,0.000009923641,0.0002122104,0.000651293,0.000108305,0.00128756,0.07487851,0.00007962643,0.002725006,0.000009954049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966191,0.0005790958,0.0008394831,0.0000432837,0.000004349699,0.000008056765,0.001422561,0.00002780577,0.000456231],"genre_scores_gemma":[0.9970464,0.0002189342,0.0006364355,0.00003912652,0.000002312851,0.000009450648,0.001440138,0.000009834947,0.0005974848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001123476,"threshold_uncertainty_score":0.00375843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02527993666198337,"score_gpt":0.3154683910550412,"score_spread":0.2901884543930578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}