{"id":"W2980842125","doi":"10.1074/jbc.ra119.009437","title":"Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope","year":2019,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Horizon 2020 Framework Programme; Cardiff University; Canolfan Ymchwil Canser Cymru; Diamond Light Source; Cancer Research UK; Cancer Research Wales; Wellcome Trust; Wellcome","keywords":"Immunogenicity; Epitope; Human leukocyte antigen; Peptide; Antigen; Biology; Virology; Molecular biology; Chemistry; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007612012,0.0001731503,0.0001007622,0.00006503685,0.00006782863,0.0001813242,0.00007896398,0.0001415028,0.0009148246],"category_scores_gemma":[0.0001088524,0.00008027074,0.000095929,0.00006135185,0.00011817,0.0001165846,0.0001167358,0.0002161233,0.0002078672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001001066,"about_ca_system_score_gemma":0.00007501744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001352615,"about_ca_topic_score_gemma":0.0001690097,"domain_scores_codex":[0.9999325,0.00001512427,0.000004472552,0.00001420049,0.0000128814,0.00002068462],"domain_scores_gemma":[0.9999692,0.000007721692,0.000008836405,0.000003262164,0.000002926559,0.00000792741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005422815,0.00001434496,0.0004412377,0.00001482989,0.000002567978,0.00002298833,0.000006246228,0.0002309168,0.9980289,0.00004204469,0.00001591265,0.001125669],"study_design_scores_gemma":[0.00002854733,0.0006840691,0.008930251,0.000005492562,0.00002285963,0.000314042,0.00005202736,0.003624485,0.98466,0.0001483737,0.001524627,0.000005230314],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983563,0.0003040109,0.0007364225,0.00002045264,0.000004630342,0.000005170828,0.0000232702,0.00001830285,0.0005313477],"genre_scores_gemma":[0.9988404,0.0001685185,0.0005855376,0.00002667426,0.000002742953,0.00000452832,0.00002994398,0.00000524544,0.000336437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009148246,"threshold_uncertainty_score":0.003060341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02200866990528214,"score_gpt":0.2619526024366196,"score_spread":0.2399439325313374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}