{"id":"W2980849295","doi":"10.1016/j.jalz.2019.06.2581","title":"P2‐174: NUMB PREVENTS NEURODEGENERATION BY REGULATING INTRANEURONAL TAU LEVELS IN AN ISOFORM‐SPECIFIC MANNER","year":2019,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"","keywords":"NUMB; Neurodegeneration; Cell biology; Tau protein; Biology; Neuroscience; Programmed cell death; Neuroprotection; Intracellular; Signal transducing adaptor protein; Gene isoform; Alzheimer's disease; Signal transduction; Pathology; Medicine; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001577589,0.0005018918,0.0004289816,0.0003713377,0.000251187,0.0003250907,0.0004120125,0.0004943704,0.001949681],"category_scores_gemma":[0.0001201683,0.0001990941,0.0002271748,0.0002053369,0.0004531777,0.0002872038,0.0002107564,0.0009119197,0.0007178077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003066267,"about_ca_system_score_gemma":0.0004377098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005421434,"about_ca_topic_score_gemma":0.0008858226,"domain_scores_codex":[0.9998454,0.00001795349,0.00001599722,0.00003788251,0.00003744652,0.00004533701],"domain_scores_gemma":[0.9999081,0.00001024577,0.00002285125,0.00001093497,0.000007651269,0.00004021369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004174106,0.0001818196,0.00008099838,0.00007949652,0.0000127062,0.00008832328,0.00001727548,0.00008999344,0.996475,0.0001611354,0.0002047486,0.002191018],"study_design_scores_gemma":[0.0002787174,0.001844112,0.003636292,0.00002241766,0.0000480351,0.0005140865,0.0000494199,0.001278725,0.984891,0.0002026935,0.007220422,0.00001405156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907277,0.002982565,0.001635673,0.00036758,0.0001512045,0.00009486497,0.0005625961,0.0002802958,0.003197574],"genre_scores_gemma":[0.9870619,0.001816396,0.002700172,0.0002670453,0.00004546903,0.0002158471,0.0008535727,0.00009572314,0.006943843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001949681,"threshold_uncertainty_score":0.006522298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03732186047249868,"score_gpt":0.3037314830928801,"score_spread":0.2664096226203814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}