{"id":"W2980853278","doi":"10.1182/blood.v118.21.1274.1274","title":"Enhanced Human Hematopoietic Stem Cell Self-Renewal Enabled by Controlling Feedback Signaling From Lineage Committed Cells","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Heart and Stroke Foundation; University Health Network; University of Toronto","funders":"","keywords":"Stem cell; Cell biology; Haematopoiesis; Biology; Paracrine signalling; Population; Progenitor cell; Hematopoietic stem cell; Transplantation; Immunology; Receptor; Medicine; Biochemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009513753,0.0002125138,0.0001364804,0.00009081556,0.00006190316,0.0002603765,0.0001544211,0.0001241811,0.0006191036],"category_scores_gemma":[0.00008090991,0.00008091546,0.0001145873,0.00008901979,0.000115937,0.0000970245,0.0001537697,0.0001853132,0.0001539124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002143827,"about_ca_system_score_gemma":0.0001577166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004967954,"about_ca_topic_score_gemma":0.0005210539,"domain_scores_codex":[0.9999635,0.000004836103,0.0000019444,0.000007908366,0.00001429438,0.000007520997],"domain_scores_gemma":[0.9999752,0.000006771084,0.000007111441,0.000002610605,0.00000353704,0.000004668607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006133416,0.00002816907,0.0002504006,0.00001977733,0.000002386067,0.00001212343,0.000007102166,0.003116027,0.9930884,0.0001636027,0.00004341114,0.003207298],"study_design_scores_gemma":[0.00001713611,0.0001637292,0.0009190772,0.000003137569,0.000007451951,0.00001895948,0.000008327733,0.04797883,0.9498721,0.00008849103,0.0009182033,0.000004576933],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863391,0.0003535242,0.01211031,0.00003216442,0.00001302873,0.00001390133,0.0001077357,0.0001429408,0.0008872434],"genre_scores_gemma":[0.9959497,0.0001338945,0.003447471,0.000008973158,0.000002018084,0.00001180668,0.00005257904,0.00001135253,0.0003821436],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006191036,"threshold_uncertainty_score":0.002071142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008658037150456273,"score_gpt":0.2079047436335778,"score_spread":0.1992467064831215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}