{"id":"W2980860480","doi":"10.1016/j.celrep.2019.09.004","title":"Functional Redundancy between β1 and β3 Integrin in Activating the IR/Akt/mTORC1 Signaling Axis to Promote ErbB2-Driven Breast Cancer","year":2019,"lang":"en","type":"article","venue":"Cell Reports","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Memorial Chiropractic College; McGill University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"mTORC1; Breast cancer; Cancer research; Protein kinase B; PI3K/AKT/mTOR pathway; Signal transduction; Integrin; Cell biology; Cancer; Chemistry; Biology; Medicine; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001747998,0.0003018127,0.0001585517,0.00020561,0.0001575995,0.0003877174,0.0001562147,0.0001974046,0.00112868],"category_scores_gemma":[0.0000641919,0.0001306706,0.0002104863,0.000130352,0.0001527149,0.0001607158,0.0001660453,0.0004638685,0.0002943899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002961513,"about_ca_system_score_gemma":0.0002674601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003815879,"about_ca_topic_score_gemma":0.0008938939,"domain_scores_codex":[0.9998519,0.00002764187,0.00001323037,0.00002149727,0.00003685377,0.00004882825],"domain_scores_gemma":[0.9999416,0.000006558948,0.00002077398,0.000006084517,0.000004843914,0.00002015937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008493374,0.00001885726,0.0003082764,0.00002480687,0.00000574972,0.0000482351,0.000006057505,0.00005607593,0.9981127,0.0002190617,0.00004675267,0.001068533],"study_design_scores_gemma":[0.00004062287,0.000339678,0.01347565,0.00000936075,0.00005808169,0.0008996336,0.00004219794,0.001434871,0.978088,0.0001356356,0.005470473,0.000005818783],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931438,0.002339211,0.001764287,0.0001725755,0.00002457757,0.00001795972,0.0002720989,0.00007476094,0.002190742],"genre_scores_gemma":[0.99721,0.0005696468,0.0009733322,0.0000514485,0.00000585939,0.00001753408,0.000225994,0.00001021162,0.0009360082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00112868,"threshold_uncertainty_score":0.003775775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0234632097434345,"score_gpt":0.293653613356759,"score_spread":0.2701904036133245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}