{"id":"W2980860480","doi":"10.1016/j.celrep.2019.09.004","title":"Functional Redundancy between β1 and β3 Integrin in Activating the IR/Akt/mTORC1 Signaling Axis to Promote ErbB2-Driven Breast Cancer","year":2019,"lang":"en","type":"article","venue":"Cell Reports","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Memorial Chiropractic College; McGill University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"mTORC1; Breast cancer; Cancer research; Protein kinase B; PI3K/AKT/mTOR pathway; Signal transduction; Integrin; Cell biology; Cancer; Chemistry; Biology; Medicine; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005900813,0.0001880642,0.0003250581,0.0001777412,0.00009178457,0.00004643563,0.00008661256,0.0001095302,0.0009025233],"category_scores_gemma":[0.0001650542,0.0001356548,0.00007228139,0.0003944598,0.00005391788,0.00007941126,0.0002011824,0.0005947491,0.00004936076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002598651,"about_ca_system_score_gemma":0.000326114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005494592,"about_ca_topic_score_gemma":0.00003253311,"domain_scores_codex":[0.9978715,0.00006765196,0.0004826594,0.0005635603,0.0006211438,0.0003935371],"domain_scores_gemma":[0.9988078,0.0001480302,0.00017219,0.0004663716,0.000172256,0.0002333159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001106181,0.00006477076,0.4539084,0.0001694863,0.00003706803,0.0003758047,0.0006990481,0.0001729662,0.5213532,0.000002820409,0.0006769749,0.02242876],"study_design_scores_gemma":[0.000969718,0.0002653845,0.7598434,0.0009928434,0.00005461134,0.0006803697,0.0006272729,0.0002959454,0.224007,0.0001026833,0.01180201,0.0003587629],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939797,0.0001959916,0.00009948112,0.001353985,0.0001517996,0.001006415,0.000004831011,0.00003295657,0.003174834],"genre_scores_gemma":[0.9933289,0.00001525042,0.0003601658,0.0001374714,0.0002811886,0.00006443872,0.00001949102,0.00004233494,0.005750705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.305935,"threshold_uncertainty_score":0.9881998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0234632097434345,"score_gpt":0.293653613356759,"score_spread":0.2701904036133245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}