{"id":"W2980861407","doi":"10.1182/blood.v122.21.2893.2893","title":"ALDH Genes and Reactive Aldehydes Play Important Roles in HSCs and Leukemia and May Be Exploited to Treat AML","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Leukemia; Acute leukemia; Biology; Cancer research; Haematopoiesis; Reactive oxygen species; Cell biology; DNA damage; Signal transduction; Chemistry; Stem cell; Biochemistry; Immunology; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001828276,0.0002691472,0.0001495675,0.0002826885,0.000108487,0.0001745264,0.0001268321,0.0002201342,0.001016646],"category_scores_gemma":[0.00008172224,0.00007426296,0.0002040692,0.0001960346,0.0002305516,0.0001551638,0.0001569957,0.0003797622,0.0001579342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000176072,"about_ca_system_score_gemma":0.0001319478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001763168,"about_ca_topic_score_gemma":0.0002234066,"domain_scores_codex":[0.9999491,0.00001261695,0.000004652396,0.000007953799,0.0000149028,0.00001077967],"domain_scores_gemma":[0.9999428,0.000008575745,0.0000250904,0.000003942562,0.000005609284,0.00001409538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001046597,0.0001648787,0.004398932,0.0003576078,0.00005134348,0.0006606713,0.00006554618,0.0007876579,0.9340884,0.00285142,0.000640661,0.05488633],"study_design_scores_gemma":[0.0002005384,0.002559461,0.02421344,0.00004480446,0.0001347378,0.00365062,0.00007825633,0.001621212,0.9178616,0.002886969,0.04672761,0.00002080164],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9178922,0.06173883,0.01168965,0.001600416,0.0001723988,0.0001092244,0.0004746315,0.0003355982,0.005987021],"genre_scores_gemma":[0.9863124,0.008342178,0.002071834,0.0001756562,0.0000592978,0.00003527701,0.0002263993,0.00000887874,0.002768054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001016646,"threshold_uncertainty_score":0.003401041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01768209477662428,"score_gpt":0.2742593570421745,"score_spread":0.2565772622655502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}