{"id":"W2980886823","doi":"10.1016/j.tiv.2019.104695","title":"LONP1 induction by SRT1720 attenuates mitochondrial dysfunction against high glucose induced neurotoxicity in PC12 cells","year":2019,"lang":"en","type":"article","venue":"Toxicology in Vitro","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"Mitochondrion; Biology; Cell biology; SIRT3; Neurotoxicity; Mitophagy; Bioenergetics; Biochemistry; Internal medicine; Apoptosis; Sirtuin; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002421399,0.0003055087,0.0003999944,0.0002363261,0.00005520217,0.00001983115,0.0002171977,0.0008933607,0.0001870991],"category_scores_gemma":[0.0001409651,0.0003269833,0.00009707271,0.0003002166,0.00008489023,0.00001851168,0.0001214486,0.0005506276,0.0002529892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009298733,"about_ca_system_score_gemma":0.00009202702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001053159,"about_ca_topic_score_gemma":0.000250773,"domain_scores_codex":[0.9975287,0.0004732316,0.0004990817,0.0008302545,0.000143603,0.0005251269],"domain_scores_gemma":[0.9991929,0.00005299465,0.0001758924,0.0004181666,0.00005662789,0.0001034114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001580511,0.000291134,0.003372677,0.00001240842,0.00001657872,0.00001459872,0.00003751589,0.0001453543,0.9905499,0.00001055892,0.002781314,0.001187494],"study_design_scores_gemma":[0.003290823,0.0008759011,0.005588648,0.00000761477,0.000009290459,0.00001868761,0.00005157642,0.00008198532,0.9830306,0.00004022053,0.006688182,0.0003165031],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920546,0.00005913436,0.0001790185,0.000353116,0.005921161,0.0008968032,0.00003588016,0.00003253559,0.0004677162],"genre_scores_gemma":[0.9959104,0.0000736123,0.0002438712,0.001648795,0.0006185003,0.0001424435,0.0004357265,0.00003930444,0.0008873178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007519288,"threshold_uncertainty_score":0.9999182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00884611582747595,"score_gpt":0.2258460660958417,"score_spread":0.2169999502683658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}