{"id":"W2980903527","doi":"10.1136/gutjnl-2019-iddfabstracts.278","title":"IDDF2019-ABS-0169 A phase 3 study comparing switching from tenofovir disoproxil fumarate (TDF) to tenofovir alafenamide (TAF) with continued TDF treatment in virologically-suppressed patients with chronic hepatitis B (CHB): week 48 efficacy and safety results","year":2019,"lang":"en","type":"article","venue":"","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of Toronto","funders":"","keywords":"Medicine; Tenofovir alafenamide; Gastroenterology; Internal medicine; Discontinuation; HBeAg; Creatinine; Renal function; Population; Clinical endpoint; Viremia; Placebo; Fanconi syndrome; Urology; Randomized controlled trial; Hepatitis B virus; Viral load; Kidney; Immunology; Antibody; HBsAg; Pathology; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001412316,0.001246257,0.001841087,0.0003741748,0.000413286,0.0008732632,0.0007188973,0.001576753,0.006426342],"category_scores_gemma":[0.0008030813,0.0004811381,0.001357955,0.0003470899,0.0007961209,0.0005127708,0.0002424741,0.003072249,0.001221574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007558405,"about_ca_system_score_gemma":0.00143358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001633971,"about_ca_topic_score_gemma":0.003736527,"domain_scores_codex":[0.9995164,0.000234597,0.0000265809,0.00005918008,0.00004537987,0.0001179205],"domain_scores_gemma":[0.9993107,0.0001452281,0.0001219833,0.00003988273,0.00005393488,0.0003281692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8818139,0.03664431,0.002582755,0.0004360607,0.0007916519,0.0001201101,0.00009934991,0.0008174748,0.02424625,0.0001919688,0.003042336,0.04921379],"study_design_scores_gemma":[0.7598453,0.2319594,0.004419387,0.00002333698,0.0002252599,0.00009593807,0.00002267074,0.0005007444,0.001410163,0.00009919193,0.001379715,0.00001891693],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875097,0.001699658,0.0005606571,0.0005626383,0.0002486914,0.003502498,0.002639087,0.0001515625,0.003125353],"genre_scores_gemma":[0.9840424,0.001147947,0.002077257,0.001530779,0.0003127095,0.003551608,0.003323598,0.00004897284,0.003964793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006426342,"threshold_uncertainty_score":0.0214982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01524871634047339,"score_gpt":0.262342668682234,"score_spread":0.2470939523417607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}