{"id":"W2980964793","doi":"10.1161/circgen.119.002617","title":"Genetic Association Analyses Highlight <i>IL6</i> , <i>ALPL</i> , and <i>NAV1</i> As 3 New Susceptibility Genes Underlying Calcific Aortic Valve Stenosis","year":2019,"lang":"en","type":"review","venue":"Circulation Genomic and Precision Medicine","topic":"Cardiac Valve Diseases and Treatments","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"Medical Research Council; Agence Nationale de la Recherche; British Heart Foundation","keywords":"Genome-wide association study; Candidate gene; Biology; Allele; Genetic association; Expression quantitative trait loci; Genetics; Gene; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005699758,0.0007452242,0.002903736,0.0004068878,0.0002194078,0.00008485671,0.000122818,0.0005593997,0.0003036267],"category_scores_gemma":[0.0003909223,0.0005580318,0.001456267,0.0004709009,0.0001025427,0.0001107087,0.0001181369,0.000340048,0.0001501116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007397467,"about_ca_system_score_gemma":0.0006841345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000325758,"about_ca_topic_score_gemma":0.000002941887,"domain_scores_codex":[0.9957995,0.0003503417,0.001364876,0.001239471,0.0007992506,0.0004465558],"domain_scores_gemma":[0.9963431,0.0008985419,0.0009047114,0.0008171512,0.0002215342,0.0008149293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006104438,0.00007984966,0.08799552,0.00480896,0.002625671,0.000009116619,0.0001603688,0.00001478737,0.0001196372,0.00001107673,0.001850476,0.9022635],"study_design_scores_gemma":[0.005297115,0.0006122629,0.4471797,0.01109451,0.06134389,0.0001560151,0.0002012383,0.000137975,0.000002554024,0.0005045685,0.4723781,0.001092061],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03974484,0.9563125,0.0003034201,0.000183083,0.0006833401,0.002194714,0.00006978456,0.00006933056,0.0004390285],"genre_scores_gemma":[0.03279584,0.9641457,0.0001472539,0.0003789042,0.0006380698,0.00004622851,0.0007134937,0.00009993905,0.001034608],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9011714,"threshold_uncertainty_score":0.9996871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1262428347057631,"score_gpt":0.4328888653474131,"score_spread":0.30664603064165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}