{"id":"W2980964793","doi":"10.1161/circgen.119.002617","title":"Genetic Association Analyses Highlight <i>IL6</i> , <i>ALPL</i> , and <i>NAV1</i> As 3 New Susceptibility Genes Underlying Calcific Aortic Valve Stenosis","year":2019,"lang":"en","type":"review","venue":"Circulation Genomic and Precision Medicine","topic":"Cardiac Valve Diseases and Treatments","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"Medical Research Council; Agence Nationale de la Recherche; British Heart Foundation","keywords":"Genome-wide association study; Candidate gene; Biology; Allele; Genetic association; Expression quantitative trait loci; Genetics; Gene; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001080497,0.0008609134,0.0005577693,0.001266297,0.0003543553,0.001047339,0.0005795336,0.0005637634,0.003579205],"category_scores_gemma":[0.0017939,0.0001769205,0.002272985,0.001700193,0.0003662422,0.0002273113,0.0004866396,0.0008795112,0.0003253698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002948719,"about_ca_system_score_gemma":0.0004663742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001537024,"about_ca_topic_score_gemma":0.002125992,"domain_scores_codex":[0.9995224,0.00009200157,0.00004113384,0.0001748347,0.0001012261,0.00006830947],"domain_scores_gemma":[0.9983723,0.0007474812,0.0004759965,0.0001299296,0.0001169956,0.0001573904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002524516,0.0001063284,0.9217839,0.0002574379,0.004010705,0.001525329,0.0001548492,0.001792816,0.03926219,0.0006298248,0.0007422481,0.02720981],"study_design_scores_gemma":[0.0002352443,0.0004664416,0.9737276,0.00008488354,0.00539811,0.002511942,0.0001498489,0.004208341,0.008329531,0.001817655,0.003032892,0.00003754627],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9864758,0.003776002,0.006428434,0.0004585353,0.00004707856,0.00002626512,0.001442773,0.0001689233,0.001176192],"genre_scores_gemma":[0.9922088,0.001044783,0.004890349,0.0001382028,0.00008491716,0.00002634276,0.001211304,0.00003050375,0.000364825],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.003579205,"threshold_uncertainty_score":0.01197362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1262428347057631,"score_gpt":0.4328888653474131,"score_spread":0.30664603064165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}