{"id":"W2980977351","doi":"10.1002/mas.21607","title":"STRATEGIES AND CHALLENGES IN METHOD DEVELOPMENT AND VALIDATION FOR THE ABSOLUTE QUANTIFICATION OF ENDOGENOUS BIOMARKER METABOLITES USING LIQUID CHROMATOGRAPHY‐TANDEM MASS SPECTROMETRY","year":2019,"lang":"en","type":"review","venue":"Mass Spectrometry Reviews","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Hospital; Saskatoon City Hospital; University of Saskatchewan","funders":"","keywords":"Metabolomics; Bioanalysis; Biomarker; Chemistry; Drug development; Biomarker discovery; Analyte; Computational biology; Biochemical engineering; Chromatography; Proteomics; Pharmacology; Drug; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003233024,0.0007966919,0.002957253,0.0008946536,0.0001835418,0.0001258339,0.000433408,0.0004046761,0.000009343271],"category_scores_gemma":[0.0001997751,0.0005627363,0.0005655704,0.0009925443,0.0001479761,0.00002926496,0.0001974145,0.0002537668,0.000002176035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008807829,"about_ca_system_score_gemma":0.0002355325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001260936,"about_ca_topic_score_gemma":0.00001219033,"domain_scores_codex":[0.9958746,0.0005367278,0.001607343,0.001145218,0.0002572463,0.0005788186],"domain_scores_gemma":[0.9972837,0.0003324031,0.001352275,0.0008420482,0.0001062303,0.00008335904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001148979,0.0001685138,0.00004846754,0.06193673,0.003170779,0.000003896825,0.0001487719,0.000003933676,0.4138855,0.01535368,0.00003695484,0.5051278],"study_design_scores_gemma":[0.0004928458,0.0003161216,0.0001209968,0.001695507,0.001906981,0.00008942987,0.000529227,0.00003879642,0.01559124,0.0001445824,0.9782698,0.0008044781],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004869311,0.9688751,0.0272859,0.00003763636,0.0002310533,0.002733212,0.00006473876,0.00001494339,0.0002705296],"genre_scores_gemma":[0.0004957729,0.9056356,0.09314143,0.000006004548,0.0001415314,0.0003284926,0.0001511063,0.00007976818,0.00002028745],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9782329,"threshold_uncertainty_score":0.9996824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2287122209365436,"score_gpt":0.3685513734583469,"score_spread":0.1398391525218033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}