{"id":"W2980977351","doi":"10.1002/mas.21607","title":"STRATEGIES AND CHALLENGES IN METHOD DEVELOPMENT AND VALIDATION FOR THE ABSOLUTE QUANTIFICATION OF ENDOGENOUS BIOMARKER METABOLITES USING LIQUID CHROMATOGRAPHY‐TANDEM MASS SPECTROMETRY","year":2019,"lang":"en","type":"review","venue":"Mass Spectrometry Reviews","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Hospital; Saskatoon City Hospital; University of Saskatchewan","funders":"","keywords":"Metabolomics; Bioanalysis; Biomarker; Chemistry; Drug development; Biomarker discovery; Analyte; Computational biology; Biochemical engineering; Chromatography; Proteomics; Pharmacology; Drug; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.05194772,0.002570158,0.002842218,0.004894956,0.001288253,0.00513473,0.004868514,0.004269341,0.00128781],"category_scores_gemma":[0.02383361,0.001621104,0.002520787,0.002722889,0.004204803,0.005915941,0.004450145,0.006206725,0.002281183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002515744,"about_ca_system_score_gemma":0.009064524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002836566,"about_ca_topic_score_gemma":0.003458077,"domain_scores_codex":[0.9643609,0.01279718,0.003220272,0.005867947,0.01276939,0.000984361],"domain_scores_gemma":[0.9782578,0.01012363,0.002295967,0.001666781,0.007257269,0.0003986093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0003418151,0.0004068325,0.007222514,0.02729048,0.001149327,0.002079728,0.00147947,0.01080443,0.1986921,0.05101871,0.01272078,0.6867939],"study_design_scores_gemma":[0.0001636418,0.001604215,0.009515736,0.008469874,0.001172768,0.0061994,0.001970285,0.03893629,0.2422138,0.07204143,0.6167342,0.0009784205],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"review","genre_scores_codex":[0.01884996,0.3656958,0.5928666,0.01060534,0.001450479,0.001603963,0.0006944511,0.0008522793,0.007381116],"genre_scores_gemma":[0.08298253,0.2608081,0.6373591,0.008514474,0.00130655,0.003085225,0.001696263,0.0004409208,0.003806859],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.05194772,"threshold_uncertainty_score":0.2747291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2287122209365436,"score_gpt":0.3685513734583469,"score_spread":0.1398391525218033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}