{"id":"W2981054177","doi":"10.1182/blood.v124.21.3040.3040","title":"Genetic Alterations of the MHC Class II Transactivator CIITA Are Frequent in Primary Mediastinal Large B-Cell Lymphoma and Associated with Diminished MHC Class II Expression","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"CIITA; Biology; Genetics; MHC class I; MHC class II; Major histocompatibility complex; Cancer research; Computational biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002280977,0.0003136637,0.0002567569,0.0009829374,0.0001793061,0.0003167913,0.0002123455,0.0003073141,0.001673427],"category_scores_gemma":[0.0005887622,0.0001708703,0.0001350401,0.0006260703,0.0003952981,0.0001181423,0.0002298591,0.0002611164,0.0003963178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001972183,"about_ca_system_score_gemma":0.0001070934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005043782,"about_ca_topic_score_gemma":0.0007418498,"domain_scores_codex":[0.9997861,0.00002158711,0.00002179371,0.00007345012,0.00006320242,0.00003386552],"domain_scores_gemma":[0.9995059,0.0001033938,0.0002426804,0.00004140456,0.00003962608,0.00006698318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005118451,0.00005899445,0.4159439,0.0001610422,0.00009796789,0.006268382,0.0002549077,0.0001692662,0.566911,0.00005899141,0.0002036057,0.009360023],"study_design_scores_gemma":[0.00001928077,0.0001310035,0.9345292,0.00001128891,0.0000781799,0.02423135,0.0001149646,0.0003288435,0.03972098,0.00007813697,0.0007492388,0.000007557513],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985687,0.0004282285,0.0004681663,0.00001695139,0.000002975202,0.000008809004,0.0001546724,0.00003112804,0.0003204049],"genre_scores_gemma":[0.9992555,0.0001233161,0.0003386978,0.00001192093,0.000005658349,0.000005315725,0.0001655734,0.000006376217,0.00008772514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001673427,"threshold_uncertainty_score":0.005598187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006556340353814989,"score_gpt":0.1959373157191068,"score_spread":0.1893809753652918,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}