{"id":"W2981074229","doi":"10.1016/j.jalz.2019.08.071","title":"P4‐524: PROTEOLYTIC CLEAVAGE OF TAU IN CORTICOBASAL DEGENERATION AND PROGRESSIVE SUPRANUCLEAR PALSY PATHOGENESIS","year":2019,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"","keywords":"Progressive supranuclear palsy; Tauopathy; Granzyme; Tau protein; Corticobasal degeneration; Chemistry; Biology; Molecular biology; Cell biology; Biochemistry; Perforin; Neurodegeneration; Alzheimer's disease; Genetics; In vitro; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002015035,0.0005689264,0.0002574189,0.0005483164,0.0002892541,0.0005244466,0.0003156096,0.0006698103,0.002460049],"category_scores_gemma":[0.0002566455,0.0001610883,0.0004447438,0.0004311822,0.0002459965,0.0002628102,0.0003872586,0.0004368024,0.001523448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004485327,"about_ca_system_score_gemma":0.0002876524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001164721,"about_ca_topic_score_gemma":0.000511955,"domain_scores_codex":[0.9998587,0.00001886258,0.00001761616,0.00004094865,0.00004179546,0.00002193718],"domain_scores_gemma":[0.9999062,0.000008690295,0.00004219229,0.000007696033,0.00001921752,0.000016041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0012219,0.0001005785,0.01812957,0.0004579563,0.00007459758,0.004894798,0.0001202353,0.0003306553,0.9564245,0.0003041789,0.0006259831,0.01731506],"study_design_scores_gemma":[0.00009317404,0.0009441572,0.2579406,0.0001559729,0.0002217488,0.03956778,0.0002177422,0.002125328,0.6772618,0.00125214,0.020178,0.00004159318],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814589,0.008423693,0.003341281,0.0002218097,0.00004476935,0.00006195273,0.001118334,0.0001016732,0.005227467],"genre_scores_gemma":[0.9831902,0.004597944,0.00329,0.0001231808,0.00003177833,0.0000466681,0.002968896,0.00002851736,0.005722913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002460049,"threshold_uncertainty_score":0.008229733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02097643921774681,"score_gpt":0.2876012559791109,"score_spread":0.2666248167613641,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}