{"id":"W2981084584","doi":"10.1101/19008318","title":"APOE interacts with tau PET to influence memory independently of amyloid PET","year":2019,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Foundation for the National Institutes of Health; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; National Institute on Aging; Alzheimer's Association; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Science Foundation","keywords":"Apolipoprotein E; Psychology; Dementia; Cognition; Neuroimaging; Temporal lobe; Amyloid (mycology); Association (psychology); Neuroscience; Alzheimer's disease; Alzheimer's Disease Neuroimaging Initiative; Disease; Internal medicine; Medicine; Cognitive impairment; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001607085,0.0004642429,0.0003233733,0.000409336,0.0001718499,0.0007027736,0.0002335804,0.0002533942,0.001762378],"category_scores_gemma":[0.00427607,0.0001982124,0.0004875775,0.0003337748,0.0002654064,0.0003563175,0.0002120367,0.0002720161,0.0001869046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001661394,"about_ca_system_score_gemma":0.0002147646,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002346888,"about_ca_topic_score_gemma":0.003195143,"domain_scores_codex":[0.9995713,0.0002304535,0.00003977028,0.00006656889,0.00005251629,0.00003935818],"domain_scores_gemma":[0.9981182,0.0009414661,0.0006050841,0.0001612664,0.0001006578,0.00007341953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002577776,0.0001325678,0.9812619,0.00004080393,0.0005199081,0.0002289957,0.000104819,0.0003566678,0.003327149,0.0001640814,0.0001943189,0.01109096],"study_design_scores_gemma":[0.00005302903,0.0003409536,0.9936728,0.0000206676,0.0004863989,0.0005435665,0.00007314072,0.001457506,0.002132646,0.0007786936,0.0004337825,0.000006807606],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974725,0.0008312677,0.0005028667,0.00009881688,0.000007069385,0.000005592397,0.0001471403,0.000009747696,0.0009251198],"genre_scores_gemma":[0.9990651,0.0001453682,0.0002461909,0.00003556749,0.000008535237,0.000004327506,0.00007874364,0.000003403859,0.0004127389],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002346888,"threshold_uncertainty_score":0.008499205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02192623148563053,"score_gpt":0.3133007919616537,"score_spread":0.2913745604760232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}