{"id":"W2981115842","doi":"10.1158/1078-0432.ccr-19-1164","title":"Lucitanib for the Treatment of HR+/HER2− Metastatic Breast Cancer: Results from the Multicohort Phase II FINESSE Study","year":2019,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Institut de Recherches Servier; Servier","keywords":"Medicine; Internal medicine; Clinical endpoint; Oncology; Breast cancer; Metastatic breast cancer; Fibroblast growth factor receptor 1; Cohort; Cancer; Adverse effect; Randomized controlled trial; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003307024,0.0008858509,0.0009549932,0.0002460435,0.0002592939,0.0006715747,0.0004392113,0.0004562759,0.001352652],"category_scores_gemma":[0.0009418709,0.0002398,0.0009167718,0.0002886816,0.0003336498,0.0003229934,0.0002826537,0.0007302281,0.0003056192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007425839,"about_ca_system_score_gemma":0.0008204608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001413065,"about_ca_topic_score_gemma":0.003991586,"domain_scores_codex":[0.9994166,0.0003669192,0.00002291699,0.00006564366,0.00006075622,0.00006725222],"domain_scores_gemma":[0.9994546,0.00009304858,0.0001290059,0.00006898567,0.00005957392,0.0001948061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6173921,0.01647479,0.09964168,0.001100752,0.008235035,0.0004066693,0.0004529331,0.003958569,0.05006533,0.0004165808,0.01319791,0.1886576],"study_design_scores_gemma":[0.3788655,0.1996186,0.390827,0.0001602716,0.005812735,0.001355882,0.0001511894,0.002184627,0.005887755,0.000470689,0.01454579,0.000120064],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905414,0.004884103,0.0005099625,0.0003200664,0.00003479814,0.0007374192,0.001483097,0.00006304861,0.00142598],"genre_scores_gemma":[0.9904275,0.001718605,0.001104346,0.0006556594,0.00006374087,0.0005744869,0.004224848,0.00002529727,0.001205447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003307024,"threshold_uncertainty_score":0.01748943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1920115313090569,"score_gpt":0.5330753072108346,"score_spread":0.3410637759017777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}