{"id":"W2981121770","doi":"10.1128/aac.01601-19","title":"THP-1 and <i>Dictyostelium</i> Infection Models for Screening and Characterization of Anti-Mycobacterium abscessus Hit Compounds","year":2019,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Mycobacterium research and diagnosis","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Cystic Fibrosis Canada; Medicines for Malaria Venture; GlaxoSmithKline","keywords":"Mycobacterium abscessus; Microbiology; Dictyostelium; Biology; Mycobacterium; Virology; Bacteria; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004980699,0.0005374713,0.0005084292,0.0003848591,0.0002946328,0.0002915176,0.0003303454,0.0004040753,0.001781553],"category_scores_gemma":[0.0001910369,0.0001674037,0.0003202919,0.0002850694,0.0002298525,0.0002197622,0.0002764796,0.000880678,0.0007807502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003129247,"about_ca_system_score_gemma":0.0004455706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001155736,"about_ca_topic_score_gemma":0.002881866,"domain_scores_codex":[0.999582,0.0001185434,0.0000422087,0.00004862503,0.0001339191,0.00007477617],"domain_scores_gemma":[0.9997621,0.00006883193,0.00004466358,0.00003623616,0.0000557292,0.00003232577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001074642,0.00004902758,0.0002168993,0.00006984871,0.000004199016,0.00004058472,0.00001777744,0.00006056617,0.9982323,0.0001484036,0.0002362172,0.0008167459],"study_design_scores_gemma":[0.00002829325,0.0007012421,0.001945944,0.00001341791,0.00002098361,0.0003001202,0.00005736669,0.0007693342,0.9906521,0.000059829,0.005441168,0.00001012256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.918463,0.006320674,0.05214768,0.001257182,0.0003441094,0.0008057852,0.01070993,0.0005453583,0.009406301],"genre_scores_gemma":[0.8980758,0.005142128,0.0727587,0.0005920819,0.00007488947,0.001134721,0.009646912,0.0001241723,0.01245054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001781553,"threshold_uncertainty_score":0.005959868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01870791731173351,"score_gpt":0.2655733076708597,"score_spread":0.2468653903591262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}