{"id":"W2981153544","doi":"10.1053/j.gastro.2019.10.014","title":"Controversies Around Measuring Drug Toxicity: US Food and Drug Administration and Gastrointestinal Perspectives","year":2019,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Gastrointestinal motility and disorders","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"U.S. Food and Drug Administration; McMaster University; American Gastroenterological Association; Georgetown University","keywords":"Food and drug administration; Medicine; Drug; Drug development; Toxicity; Drug administration; Drug toxicity; Pharmacology; Intensive care medicine; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1406461,0.001512714,0.00391973,0.006869358,0.004040145,0.012313,0.005604932,0.02267072,0.005151499],"category_scores_gemma":[0.2193425,0.001174185,0.003216472,0.00657498,0.01893179,0.01589597,0.006214819,0.02559223,0.001774125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01007175,"about_ca_system_score_gemma":0.01909164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02118024,"about_ca_topic_score_gemma":0.0362452,"domain_scores_codex":[0.9139181,0.04164733,0.01262621,0.006490558,0.02334353,0.001974117],"domain_scores_gemma":[0.6503112,0.2477194,0.0222844,0.007558741,0.06565318,0.006473138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007537424,0.000331737,0.02424035,0.00350362,0.0007965568,0.0007207269,0.001636009,0.0009462914,0.001019969,0.1046442,0.448881,0.4125258],"study_design_scores_gemma":[0.0003266273,0.0005680448,0.01928303,0.0207134,0.001032072,0.002199529,0.004369086,0.001999911,0.00171574,0.158421,0.7889423,0.0004292353],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.002152756,0.172029,0.002287316,0.8071154,0.01006302,0.00001948709,0.0002752822,0.00005758771,0.006000174],"genre_scores_gemma":[0.07250672,0.1322521,0.01382748,0.7423223,0.0366743,0.0001225114,0.0004116112,0.0001145771,0.001768382],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1406461,"threshold_uncertainty_score":0.7438163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01040560981422407,"score_gpt":0.2218613536029512,"score_spread":0.2114557437887271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}