{"id":"W2981158858","doi":"10.1182/blood-2018-99-111304","title":"Chemogenomic Profiling of Complex Karyotype AML Reveals a Novel Susceptibility to G2/M Checkpoint Inhibition Mediated By HMGA2 Overexpression","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer; Hôpital Maisonneuve-Rosemont; Université de Montréal","funders":"","keywords":"Transcriptome; Biology; Gene expression profiling; Cancer research; NPM1; Myeloid leukemia; HMGA2; Karyotype; Gene signature; CEBPA; Leukemia; Gene; Oncology; Internal medicine; Genetics; Medicine; Gene expression; microRNA; Mutation; Chromosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008188114,0.0001717329,0.0001736673,0.0003280012,0.0001183266,0.000225446,0.00008354925,0.0001552954,0.000935754],"category_scores_gemma":[0.0001074537,0.00007073836,0.0001677553,0.0002312201,0.000152795,0.00007656244,0.0001586541,0.0001840797,0.0001933446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000139655,"about_ca_system_score_gemma":0.00008077284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002511418,"about_ca_topic_score_gemma":0.000359606,"domain_scores_codex":[0.9999261,0.000006591064,0.000004395505,0.00002261487,0.00002493072,0.00001540921],"domain_scores_gemma":[0.9999313,0.00001269639,0.00002475718,0.000009625579,0.000008557077,0.00001301318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002304607,0.00001304276,0.004400332,0.00002209415,0.00001037358,0.00005418234,0.00001295479,0.00006423631,0.9937434,0.00002700917,0.0000441203,0.001377765],"study_design_scores_gemma":[0.00002877409,0.0005201381,0.244252,0.000007430516,0.00007695999,0.000870736,0.0000965941,0.00182454,0.750078,0.0001262675,0.002108682,0.000009921561],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975102,0.0004567171,0.0007987331,0.00002628433,0.000003878008,0.00001480338,0.0008576617,0.00002931818,0.0003022881],"genre_scores_gemma":[0.9976428,0.0002053167,0.0005506519,0.00002995512,0.000004023307,0.0000213536,0.00105172,0.000007294285,0.0004869036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000935754,"threshold_uncertainty_score":0.003130436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03463543148089816,"score_gpt":0.3069147900190483,"score_spread":0.2722793585381502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}