{"id":"W2981166293","doi":"10.1016/j.clml.2019.09.033","title":"Copy number gain of the MCL1 gene locus (1q21) and acquisition of BCL2 mutation mediate resistance to venetoclax in multiple myeloma (MM) patients","year":2019,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Venetoclax; Locus (genetics); MCL1; Gene; Genetics; Cancer research; Biology; Medicine; Leukemia; Downregulation and upregulation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001646001,0.0001441552,0.0002111992,0.0005905539,0.0002329363,0.0004834757,0.000250535,0.000275965,0.003035167],"category_scores_gemma":[0.0009705247,0.0001371489,0.0001325837,0.0003598709,0.0002075351,0.0002125095,0.0002150005,0.0004159576,0.0002464734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002362072,"about_ca_system_score_gemma":0.0001262078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009205478,"about_ca_topic_score_gemma":0.0005577801,"domain_scores_codex":[0.9998683,0.0000311118,0.000007878391,0.00002189162,0.00002996073,0.00004086607],"domain_scores_gemma":[0.9996562,0.0001151977,0.0001223904,0.00002232356,0.00001777845,0.000066092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004526007,0.0006597713,0.7702905,0.00004876914,0.0001330413,0.003874482,0.0003738666,0.0005718255,0.1928348,0.0007995274,0.0008987272,0.02498879],"study_design_scores_gemma":[0.0001044026,0.0005154539,0.9779659,0.00000530341,0.00006902458,0.007729126,0.0001541382,0.0009702696,0.01126505,0.0003008035,0.0009119238,0.000008572002],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993783,0.0001369994,0.00002831774,0.00003597545,0.000002626187,0.000003291885,0.00003737867,0.000005829424,0.0003713358],"genre_scores_gemma":[0.999675,0.00003724918,0.00002408913,0.00001113402,0.000006911096,0.000001435183,0.00004576657,0.000001557794,0.000196817],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003035167,"threshold_uncertainty_score":0.01015359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02097720946676078,"score_gpt":0.3153811934989021,"score_spread":0.2944039840321414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}