{"id":"W2981197371","doi":"10.1038/s41397-019-0108-y","title":"Impact of CYP1A2, CYP2C19, and CYP2D6 genotype- and phenoconversion-predicted enzyme activity on clozapine exposure and symptom severity","year":2019,"lang":"en","type":"article","venue":"The Pharmacogenomics Journal","topic":"Schizophrenia research and treatment","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"","keywords":"Clozapine; CYP2C19; CYP1A2; CYP2D6; Pharmacology; Medicine; Dosing; Antipsychotic; Concomitant; CYP3A4; Internal medicine; Schizophrenia (object-oriented programming); Esomeprazole; Pharmacogenetics; Genotype; Cytochrome P450; Psychiatry; Chemistry; Metabolism; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001060194,0.0008111598,0.0008471329,0.0003683223,0.0003846789,0.0009920289,0.0003810799,0.000730963,0.004737041],"category_scores_gemma":[0.004681085,0.0002356507,0.002795218,0.0006413009,0.0003247205,0.0005388308,0.0004547594,0.001296209,0.0005429265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004797482,"about_ca_system_score_gemma":0.000718775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01046384,"about_ca_topic_score_gemma":0.01245101,"domain_scores_codex":[0.9988984,0.0004580166,0.00008119235,0.0002511402,0.0001549562,0.0001562628],"domain_scores_gemma":[0.9972667,0.001491192,0.0004911588,0.0002439142,0.0001586763,0.0003485047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008516443,0.000134,0.9795938,0.00003649845,0.002337875,0.0002648014,0.00007551844,0.000482461,0.001359527,0.00007773426,0.0003270071,0.006794389],"study_design_scores_gemma":[0.00007806121,0.0006404903,0.9940783,0.00001193903,0.001702123,0.0003191107,0.00009151215,0.001988412,0.0004365692,0.000146153,0.0004913568,0.00001613547],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964327,0.0007136675,0.0002860374,0.0001986151,0.00003306557,0.00001000711,0.0009373503,0.00003189568,0.001356783],"genre_scores_gemma":[0.9988373,0.00008454632,0.0001265636,0.00003342343,0.00001589289,0.000003397236,0.0003977162,0.00001496571,0.0004862916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01046384,"threshold_uncertainty_score":0.02080584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01585191635436722,"score_gpt":0.3072649339963848,"score_spread":0.2914130176420175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}