{"id":"W2981214324","doi":"10.1016/j.ymthe.2019.10.005","title":"Liver Gene Therapy: Reliable and Durable?","year":2019,"lang":"en","type":"editorial","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Hemophilia Society","funders":"","keywords":"Genetic enhancement; Factor IX; Vector (molecular biology); Medicine; Viral vector; Vectors in gene therapy; Capsid; Immunology; Transgene; Clinical trial; Gene delivery; Virology; Biology; Virus; Bioinformatics; Gene; Internal medicine; Recombinant DNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0006577262,0.000750716,0.0006161028,0.0001698342,0.0001554896,0.0001706694,0.0008454285,0.001574751,0.0001886812],"category_scores_gemma":[0.00008151223,0.0006993999,0.0003103066,0.0001877007,0.0001947068,0.00000746293,0.0002279452,0.0007860896,0.0001637674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005748894,"about_ca_system_score_gemma":0.0006479658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008858084,"about_ca_topic_score_gemma":0.00002853909,"domain_scores_codex":[0.9962382,0.0002623896,0.0003872047,0.00135882,0.0009459383,0.0008073977],"domain_scores_gemma":[0.9974725,0.00005946853,0.0002015884,0.00166122,0.0003907096,0.0002145596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00310711,0.00009073944,0.00001730219,0.00003069576,0.0004107382,0.00004530419,0.00002632465,0.00002577605,0.5752308,0.000002682861,0.4146587,0.006353855],"study_design_scores_gemma":[0.002015453,0.003048692,0.00000757583,0.00002087916,0.0000112007,0.000005660012,0.000004078008,0.00001172123,0.3960296,0.00003650123,0.5983025,0.0005061883],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"editorial","genre_scores_codex":[0.4606493,0.2291808,0.0002775612,0.0002988749,0.3049863,0.002561134,0.0003271648,0.0001145275,0.001604386],"genre_scores_gemma":[0.01615888,0.4235922,0.0007235041,0.00224831,0.527189,0.0004506074,0.004413478,0.0010302,0.02419383],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.4444904,"threshold_uncertainty_score":0.9997214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01056830349780466,"score_gpt":0.2725157364092812,"score_spread":0.2619474329114765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}